Particulate Matter Composition and Respiratory Health The PIAMA Birth Cohort Study
Particulate Matter Composition and Respiratory Health The PIAMA Birth Cohort Study
复制标题
DOI：
10.1097/ede.0000000000000264
复制
发表时间：
2015-05-01
期刊：
影响因子：
5.4
通讯作者：
Brunekreef, Bert
中科院分区：
文献类型：
--
作者：
Gehring, Ulrike;Beelen, Rob;Brunekreef, Bert
背景：环境颗粒物 (PM) 暴露与儿童的呼吸系统健康相关。人们对不同 PM 成分的重要性知之甚少。我们研究了 PM 成分对哮喘、过敏和肺功能的影响，直至 11-12 岁。方法：针对一项前瞻性出生队列研究的 3,702 名参与者，问卷报告的哮喘和花粉热以及过敏致敏和肺功能的测量结果与铜、铁、钾、镍、硫、硅、 土地利用回归模型中出生地址和当前地址直径小于 2.5 和 10 μm 的颗粒（PM2.5 和 PM10）中的钒和锌。通过多重（重复测量）逻辑回归和线性回归分析暴露-健康关系。结果：哮喘发病率以及哮喘症状和鼻炎的患病率与出生地址 PM10 中的锌呈正相关（暴露每四分位数范围增加的比值比 [95% 置信区间] 1.13 [1.02, 1.25]、1.08 [1.00, 1.17] 和 1.16 分别为[1.04，1.30]）。此外，哮喘症状与当前地址 PM10 中的铜呈正相关 (1.06 [1.00, 1.12])。过敏致敏与出生地址（相对风险[95%置信区间] 1.07 [1.01, 1.14] 和 1.10 [1.03, 1.18]）和当前地址的 PM10 中的铜和铁呈正相关。 1 秒用力呼气量与 PM2.5 中的铜和铁呈负相关（变化[95% 置信区间] -2.1% [-1.1, -0.1%] 和 -1.0% [-2.0, -0.0%]），FEF75-50 与当前地址 PM10 中的铜呈负相关（-2.3% [-4.3, -0.3%]）。结论：PM 成分，特别是铁，铜，和 锌反映了非尾气道路交通排放监管不善，可能会增加学童患哮喘和过敏的风险。
Background: Ambient particulate matter (PM) exposure is associated with children's respiratory health. Little is known about the importance of different PM constituents. We investigated the effects of PM constituents on asthma, allergy, and lung function until the age of 11-12 years.Methods: For 3,702 participants of a prospective birth cohort study, questionnaire-reported asthma and hay fever and measurements of allergic sensitization and lung function were linked with annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc in particles with diameters of less than 2.5 and 10 mu m (PM2.5 and PM10) at birth addresses and current addresses from land-use regression models. Exposure-health relations were analyzed by multiple (repeated measures) logistic and linear regressions.Results: Asthma incidence and prevalence of asthma symptoms and rhinitis were positively associated with zinc in PM10 at the birth address (odds ratio [95% confidence interval] per interquartile range increase in exposure 1.13 [1.02, 1.25], 1.08 [1.00, 1.17], and 1.16 [1.04, 1.30], respectively). Moreover, asthma symptoms were positively associated with copper in PM10 at the current address (1.06 [1.00, 1.12]). Allergic sensitization was positively associated with copper and iron in PM10 at the birth address (relative risk [95% confidence interval] 1.07 [1.01, 1.14] and 1.10 [1.03, 1.18]) and current address. Forced expiratory volume in 1 second was negatively associated with copper and iron in PM2.5 (change [95% confidence interval] -2.1% [-1.1, -0.1%] and -1.0% [-2.0, -0.0%]) and FEF75-50 with copper in PM10 at the current address (-2.3% [-4.3, -0.3%]).Conclusion: PM constituents, in particular iron, copper, and zinc, reflecting poorly regulated non-tailpipe road traffic emissions, may increase the risk of asthma and allergy in schoolchildren.