Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis.
Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis.
复制标题
极性蛋白和肌动蛋白调节蛋白是在精子发生过程中调节细胞上皮细胞粘附的不可能的伴侣。
DOI：
10.14670/hh-26.1465
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发表时间：
2011-11
影响因子：
2
通讯作者：
Lee WM
中科院分区：
文献类型：
--
作者：
Cheng CY;Wong EW;Lie PP;Mruk DD;Xiao X;Li MW;Lui WY;Lee WM
在哺乳动物睾丸中，精子发生发生在曲细精管的曲细精上皮中，由一系列细胞事件组成。这些包括：（i）精原干细胞（SSC）通过有丝分裂和SSC分化为生精细胞进行更新，（ii）减数分裂，（iii）精子发生和（iv）精子形成。在整个这些事件中，发育中的生殖细胞在广泛的细胞、生化、分子和形态变化中仍然粘附在生精上皮中的支持细胞上，以获得结构支持和营养。这些事件通过细胞连接在细胞-细胞界面处的信号转导进行协调，说明了细胞连接和粘附在精子发生中的重要性。此外，发育中的生殖细胞从干细胞生态位逐渐迁移穿过生精上皮，干细胞生态位位于邻近间质的固有膜基底膜附近的基底室中。最近的研究表明，一些表面上不相关的蛋白质，例如极性蛋白和肌动蛋白调节蛋白，实际上在精子发生的上皮周期中协同协同地协调生精上皮中支持细胞和支持细胞界面粘附的连续循环变化，使得发育中的生殖细胞在精子发生的上皮周期中保持附着在支持细胞上。 当它们改变细胞形状并迁移穿过上皮时。在这篇综述中，我们强调了极性和肌动蛋白调节蛋白影响下内吞囊泡介导的蛋白质运输事件在赋予细胞粘附和去粘附的循环事件中的生理意义。此外，这些最近的发现揭示了一些意想不到的分子，这些分子是男性避孕药开发的目标，这些分子也是毒物引起的男性生殖功能障碍的目标。
In mammalian testis, spermatogenesis takes place in the seminiferous epithelium of the seminiferous tubule, which is composed of a series of cellular events. These include: (i) spermatogonial stem cell (SSC) renewal via mitosis and differentiation of SSC to spermatogenia, (ii) meiosis, (iii) spermiogenesis, and (iv) spermiation. Throughout these events, developing germ cells remain adhered to the Sertoli cell in the seminiferous epithelium amidst extensive cellular, biochemical, molecular and morphological changes to obtain structural support and nourishment. These events are coordinated via signal transduction at the cell-cell interface through cell junctions, illustrating the significance of cell junctions and adhesion in spermatogenesis. Additionally, developing germ cells migrate progressively across the seminiferous epithelium from the stem cell niche, which is located in the basal compartment near the basement membrane of the tunica propria adjacent to the interstitium. Recent studies have shown that some apparently unrelated proteins, such as polarity proteins and actin regulatory proteins, are in fact working in concert and synergistically to coordinate the continuous cyclic changes of adhesion at the Sertoli-Sertoli and Sertoli-germ cell interface in the seminiferous epithelium during the epithelial cycle of spermatogenesis, such that developing germ cells remain attached to the Sertoli cell in the epithelium while they alter in cell shape and migrate across the epithelium. In this review, we highlight the physiological significance of endocytic vesicle-mediated protein trafficking events under the influence of polarity and actin regulatory proteins in conferring cyclic events of cell adhesion and de-adhesion. Furthermore, these recent findings have unraveled some unexpected molecules to be targeted for male contraceptive development, which are also targets of toxicant-induced male reproductive dysfunction.