Inhibition of cortical and trabecular bone formation in the long bones of immobilized monkeys.
Inhibition of cortical and trabecular bone formation in the long bones of immobilized monkeys.
复制标题
抑制固定猴子长骨中的皮质骨和小梁骨形成。
DOI：
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发表时间：
1983
影响因子：
4.2
通讯作者：
E. Morey
中科院分区：
文献类型：
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作者：
T. Wronski;E. Morey
研究了固定对幼年雄性恒河猴皮质骨和小梁骨形成的急性影响。4只动物用全身石膏固定2周。两只对照猴子被关在不同的代谢笼子里，环境和饮食条件相似。四环素衍生物在三个不同的场合被用于标记骨形成的部位。测定肱骨和股骨骨及骨小梁表面的四环素标记频率和矿物质附着率。固定对骨形成的抑制作用在小梁骨中更为明显。固定的猴子表现出适度的，但统计上不显著的，成骨百分比的减少。相反，在固定的猴子中，骨小梁表面发生骨形成的百分比的急剧下降被发现是非常显著的。骨中矿物质附着率的降低表明在固定期间皮质骨的成骨细胞活性受损。由于四环素沉积很少，因此无法可靠地确定骨小梁中的矿物附着率，这表明在固定猴子的干骺端组织中成骨细胞活性和/或招募几乎停止。
The acute effects of immobilization on cortical and trabecular bone formation were studied in juvenile male rhesus monkeys (Macaca mulatta). Four animals were immobilized for two weeks by application of total body casts. Two control monkeys were housed in separate metabolic cages under similar environmental and dietary conditions. Tetracycline derivatives were administered on three separate occasions to label sites of bone formation. The tetracycline-labeling frequency and mineral apposition rate of osteons and trabecular bone surfaces in the humerus and femur were determined. The inhibition of bone formation induced by immobilization was more pronounced in trabecular bone. Immobilized monkeys exhibited a moderate, but statistically nonsignificant, reduction in the percentage of osteons forming bone. Conversely, the dramatic decline in the percentage of trabecular surfaces undergoing bone formation in immobilized monkeys was found to be highly significant. The diminished rate of mineral apposition in osteons suggested that osteoblastic activity was impaired in cortical bone during immobilization. The mineral apposition rate in trabecular bone could not be determined reliably due to minimal tetracycline deposition, which indicated that osteoblastic activity and/or recruitment almost ceased in the metaphyseal tissue of immobilized monkeys.