RESULTS OF THALAMOTOMY FOR PARKINSON'S DISEASE.
RESULTS OF THALAMOTOMY FOR PARKINSON'S DISEASE.
复制标题
丘脑切开术治疗帕金森病的结果。
DOI：
10.1001/jama.1963.03710050119092
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发表时间：
1963
影响因子：
14.6
通讯作者：
T. J. Speakman
中科院分区：
文献类型：
--
作者：
T. J. Speakman
手术毁损丘脑腹外侧核的一部分是目前治疗失能性震颤和帕金森氏症强直的首选方法。73名患者在阿尔伯塔大学医院接受了105例丘脑切开术治疗，并在1至4年后评估日常活动功能的改善。五十六例患者好转，十二例无变化，五例死亡。只有两人的死亡与手术有关。仅1例患者出现永久性麻痹。25例患者接受了双侧手术，其中22例显示功能改善。手术禁忌症包括严重心血管疾病、智力减退及主要因运动不能、动眼危象、言语障碍或构音障碍而致残的帕金森病患者。
Surgical destruction of a portion of the ventrolateral nucleus of the thalamus is currently the procedure of choice for the treatment of incapacitating tremor and rigidity of parkinsonism. Seventy-three patients were treated by 105 thalamotomies at the University of Alberta Hospital and assessed one to four years later for improvement of function in everyday activities. Fifty-six patients were improved, 12 were unchanged, and five had died. Only two of the deaths were related to the operation. Paresis was permanent in only one patient. Twenty-five patients had bilateral operations and 22 of these showed improvement of function. Contraindications to operation include serious cardiovascular disease, mental deterioration, and those parkinsonian patients whose disability is chiefly due to akinesia, oculogyric crisis, dysphasia or dysarthria.