Kinetics and Longevity of Antibody Response to Influenza A H5N1 Virus Infection in Humans
Kinetics and Longevity of Antibody Response to Influenza A H5N1 Virus Infection in Humans
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DOI：
10.1128/cvi.00062-09
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发表时间：
2009-07-01
影响因子：
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通讯作者：
Puthavathana, Pilaipan
中科院分区：
文献类型：
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作者：
Kitphati, Rungrueng;Pooruk, Phisanu;Puthavathana, Pilaipan
抗H5N1抗体测定微量中和，血凝抑制，并在一系列的血液样本收集从8名泰国患者，包括4例死亡病例和4名幸存者的蛋白质印迹分析。早在5天就检测到抗体，通常在疾病发作后约15天配对血液中的滴度增加。抗H5抗体反应是持久的，在可以跟踪到目前为止的病例中，几乎持续了5年。此外，观察到与相关进化枝1病毒的交叉中和活性。
Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.