IP10 and Anti-HBc can Predict Virological Relapse and HBsAg Loss in Chronic Hepatitis B Patients after Nucleos(t)ide Analog Discontinuation
IP10 and Anti-HBc can Predict Virological Relapse and HBsAg Loss in Chronic Hepatitis B Patients after Nucleos(t)ide Analog Discontinuation
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DOI：
10.1159/000533515
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发表时间：
2023-06
影响因子：
2.3
通讯作者：
Yandi Xie;Minghui Li;X. Ou;S. Zheng;Yinjie Gao;Xiaoyuan Xu;Yingsi Yang;A. Ma;Jia Li;
中科院分区：
文献类型：
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作者：
Yandi Xie;Minghui Li;X. Ou;S. Zheng;Yinjie Gao;Xiaoyuan Xu;Yingsi Yang;A. Ma;Jia Li;
目的：评估血清干扰素诱导蛋白10 （IP10）和乙型肝炎核心抗体（anti-HBc）水平对核苷类似物（NA）停药后病毒学复发（VR）和乙型肝炎表面抗原（HBsAg）丢失的预测能力。方法：在这项多中心前瞻性研究中，139例患者在NA停药后随访24个月。结果：治疗结束（EOT） IP10和抗hbc分别为29.2 (5.1 ~ 66.4)pg/mL和193.6 (136.9 ~ 221.4)IU/mL。在Cox回归分析中，EOT、IP10和抗hbc是VR和HBsAg损失的独立预测因子。EOT患者的累计VR率为31.9% (vs. 70.1%)，风险比[HR] 2.998, p 26.99 pg/mL +抗- hbc≤141.35 IU/mL （vs. 73.6%, HR 6.464, p 93.5 pg/mL）为46.2% (vs. 4.7%, HR 10.94, p 93.5 pg/mL +抗- hbc≤78.42 IU/mL)， 24个月累计HBsAg损失率最高（53.8% vs. 4%, HR 16.83, p < 0.001）。结论：高EOT IP10和低EOT抗hbc水平均与较低的VR风险和较高的HBsAg丢失概率相关。
Introduction: To assess predictive ability of serum interferon-inducible protein 10 (IP10) and hepatitis B core antibody (anti-HBc) levels for virological relapse (VR) and hepatitis B surface antigen (HBsAg) loss after nucleos(t)ide analog (NA) discontinuation. Methods: In this multicenter prospective study, overall 139 patients were followed up for 24 months after NA discontinuation. Results: End of treatment (EOT) IP10 and anti-HBc were 29.2 (5.1–66.4) pg/mL and 193.6 (136.9–221.4) IU/mL. EOT IP10 and anti-HBc were independent predictors for VR and HBsAg loss in Cox regression analysis. Cumulative rates of VR in patients with EOT IP10 > 26.99 pg/mL was 31.9% (vs. 70.1%, hazard ratio [HR] 2.998, p 26.99 pg/mL plus anti-HBc ≤141.35 IU/mL (vs. 73.6%, HR 6.464, p 93.5 pg/mL was 46.2% (vs. 4.7%, HR 10.94, p 93.5 pg/mL plus anti-HBc ≤78.42 IU/mL had the highest 24-month cumulative HBsAg loss rate (53.8% vs. 4%, HR 16.83, p < 0.001). Conclusion: High EOT IP10 and low EOT anti-HBc levels were related to both lower risk of VR and higher probability of HBsAg loss.