Biochemical comparison of osteoarthritic knees with and without effusion
Biochemical comparison of osteoarthritic knees with and without effusion
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DOI：
10.1186/1471-2474-12-273
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发表时间：
2011-11-28
影响因子：
2.3
通讯作者：
Sitler, Michael R.
中科院分区：
文献类型：
--
作者：
Cattano, Nicole M.;Driban, Jeffrey B.;Sitler, Michael R.
工作背景：几种缓解疼痛的干预措施已被证明在膝关节积液的骨关节炎（OA）患者中有效;然而，并不是每个有症状的膝关节OA患者都有临床积液。结果可能过于笼统，因为与无积液膝关节相比，不清楚积液膝关节是否代表一种独特的病理状况或子集。本研究的主要目的是确定OA膝关节之间是否存在生化差异，并没有efficient.Methods：目前的横断面研究包括22名志愿者（11膝关节积液，11膝关节积液）与确认的晚期放射学膝关节OA（Kelling-Lawrence评分>= 3）。收集滑液样本，并使用定制的多重酶联免疫吸附测定法进行分析，以确定八种特定的生物标志物浓度（例如，例如，在一个实施例中，分解代谢，合成代谢）。有积液膝关节的基质金属蛋白酶（MMP）-3、基质金属蛋白酶组织抑制剂（TIMP）-1、TIMP-2和白细胞介素-10显著高于无积液膝关节。结论：有积液膝关节和无积液膝关节之间存在的生化差异支持OA亚群可能存在，其特征在于不同的生化特征和临床表现（例如，积液）。
Background: Several symptom-relieving interventions have been shown to be efficacious among osteoarthritis (OA) patients with knee effusion; however, not every symptomatic knee OA patient has clinical effusion. Results may be over-generalized since it is unclear if effused knees represent a unique pathological condition or subset compared to knees without effusion. The primary purpose of this study was to determine if biochemical differences existed between OA knees with and without effusion.Methods: The present cross-sectional study consisted of 22 volunteers (11 with knee effusion, 11 without knee effusion) with confirmed late-stage radiographic knee OA (Kellgren-Lawrence score >= 3). Synovial fluid samples were collected and analyzed using a custom multiplex enzyme-linked immunosorbent assay to determine eight specific biomarker concentrations (e. g., catabolic, anabolic).Results: Matrix metalloproteinase (MMP)-3, tissue inhibitor of MMPs (TIMP)-1, TIMP-2, and interleukin-10 were significantly higher in the knees with effusion than in the knees without effusion.Conclusions: The biochemical differences that existed between knees with and without effusion provide support that OA subsets may exist, characterized by distinct biochemical characteristics and clinical findings (e.g., effusion).