Chronic NMDA receptor blockade in early postnatal period, but not in adulthood, impairs methamphetamine-induced conditioned place preference in rats.
Chronic NMDA receptor blockade in early postnatal period, but not in adulthood, impairs methamphetamine-induced conditioned place preference in rats.
复制标题
出生后早期的慢性 NMDA 受体阻断（但在成年期则不然）会损害甲基苯丙胺诱导的大鼠条件性位置偏好。
DOI：
10.1016/j.bbr.2015.12.044
复制
发表时间：
2016
影响因子：
2.7
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Furuie;H.;Yamada;K. & Ichitani;Y.
已知动物出生后早期谷氨酸能 N-甲基-d-天冬氨酸 (NMDA) 受体阻断会在成年期产生各种行为缺陷。在本研究中，出生后（第 7-20 天）长期接受 MK-801（一种 NMDA 受体拮抗剂）治疗的大鼠，在成年后使用三室装置中的无偏差程序测试了甲基苯丙胺 (MAP) 诱导的条件性位置偏好 (CPP)。还对成年后接受相同长期治疗的大鼠进行了测试。 CPP测试包括调节前的基线测试、位置调节和调节后的偏好测试。在出生后用盐水治疗的大鼠中显示的偏好测试中，与未配对的室相比，出生后用 MK-801 治疗的大鼠没有显示出任何偏好 MAP 配对室的证据。另一方面，成年后接受 MK-801 治疗的大鼠并未受到治疗的影响，并且如盐水治疗的对照动物中所示，表现出显着的 CPP。结果表明，出生后早期而非成年期的慢性 NMDA 受体阻断可能会导致随后的经典食欲调节的持续缺陷。
Early postnatal glutamatergicN-methyl-d-aspartate (NMDA) receptor blockade in animals is known to produce various behavioral deficits in adulthood. In the present study rats postnatally (day 7–20) treated chronically with MK-801, an NMDA receptor antagonist, were tested later in adulthood in methamphetamine (MAP)-induced conditioned place preference (CPP) using a unbiased procedure in a three-compartment apparatus. Rats with the same chronic treatment in adulthood were also tested. CPP test consisted of a baseline test before conditioning, place conditioning, and a preference test after conditioning. Rats postnatally treated with MK-801 did not show any evidence of preference for MAP-paired compartment compared with that for unpaired one in the preference test that was shown in rats postnatally treated with saline. On the other hand, rats treated with MK-801 in adulthood were not affected by the treatment and showed significant CPP as was shown in saline-treated control animals. Results suggest the possibility that chronic early postnatal, but not adulthood, NMDA receptor blockade induces persistent deficit of subsequent appetitive classical conditioning.