Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells
Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells
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DOI：
10.1021/np9901837
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发表时间：
1999-09-01
影响因子：
5.1
通讯作者：
Sashida, Y
中科院分区：
文献类型：
--
作者：
Mimaki, Y;Kuroda, M;Sashida, Y
从白头翁（Pulsatilla chinensis）根的甲醇提取物制备的皂苷级分中分离出两种新的三萜皂苷（8和9）和七种先前报道的基于油酸或常春藤皂苷元的三萜皂苷（1-7），沿着两种已知的木脂素，（+）-松醇（10）和β-盾叶素（11）。新皂苷的结构通过光谱分析，包括2D NMR光谱技术和水解裂解的结果确定。对所分离的化合物及部分衍生物进行了抗HL-60人白血病细胞毒活性的评价。
Two new triterpene saponins (8 and 9) and seven previously reported triterpene saponins (1-7) based upon oleanolic acid or hederagenin, along with two known lignans, (+)-pinoresinol (10) and beta-peltatin (11), were isolated from a saponin fraction prepared from the MeOH extract of the roots of Pulsatilla chinensis. The structures of the new saponins were determined by spectroscopic analysis, including 2D NMR spectroscopic techniques, and the results of hydrolytic cleavage. The isolated compounds and some derivatives were evaluated for their cytotoxic activity against HL-60 human leukemia cells.