Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats
Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats
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DOI：
10.1016/j.lfs.2005.01.013
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发表时间：
2005-06-24
期刊：
影响因子：
6.1
通讯作者：
Takahashi, RN
中科院分区：
文献类型：
--
作者：
Da Silva, GE;Vendruscolo, LF;Takahashi, RN
本研究的目的是探讨Lewis （LEW）和自发性高血压大鼠（SHR）在高焦虑和低焦虑两种典型的焦虑/情绪模型——升高+迷宫（EPM）和开放场（of）中对乙醇影响的敏感性以及酒精饮酒行为的习得是否存在差异。研究甜味和苦味液体偏好与乙醇摄入量之间的关系也很有趣。给SHR和LEW大鼠注射生理盐水或乙醇（0.6或1.2 g/kg, ip.），并在EPM和OF中进行检测。随后，同样的动物连续自由选择水和乙醇溶液（2-8%）。另外一组动物被暴露在糖精（0.002-0.09%）或奎宁（0.0001-0.0015%）和水之间的自由选择方案中。低剂量乙醇（0.6 g/kg）主要在SHR大鼠中引起焦虑样作用和强烈的运动激活。总体而言，LEW配对者在OF测试中未受影响。在口服自我给药模式下，SHR大鼠的乙醇消耗量显著高于LEW大鼠。在其他溶液中，SHR大鼠较LEW大鼠摄入大量糖精。这些数据表明，SHR对乙醇摄入的偏好可能与它们对乙醇的焦虑/兴奋作用的不同敏感性以及该菌株对糖精强化的敏感性呈正相关。此外，这些发现提供了证据，表明SHR菌株可能是研究乙醇饮用特性的有用遗传和药理学基础。(c) 2005爱思唯尔公司版权所有。
The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivity to the effects of ethanol in the elevated plus maze (EPM) and the open field (OF), two classical models of anxiety/emotionality, as well as in the acquisition of ethanol drinking behavior. It was also of interest to examine the relationship between sweet and bitter fluids preference and ethanol intake. SHR and LEW rats were given saline or ethanol injections (0.6 or 1.2 g/kg, ip.) and tested in the EPM and OF. Subsequently the same animals were given continuous free choice between water and ethanol solution (2-8%). Additional groups of animals were exposed to a free-choice regimen between saccharin (0.002-0.09%) or quinine (0.0001-0.0015%) and water. The low dose of ethanol (0.6 g/kg) induced anxiolytic-like effects and intensive locomotor activation mainly in SHR rats tested in the OF arena. Overall, LEW counterparts were unaffected in OF test. In oral self-administration paradigm, SHR rats consumed significantly more ethanol than LEW rats. Concerning other solutions, SHR rats consumed large amounts of saccharin compared with LEW rats. These data indicate that the SHR preference for ethanol intake may be positively related to their differential sensitivity to the anxiolytic/ stimulant effects of ethanol and to the sensitivity of this strain for saccharin reinforcement. In addition, these findings provide evidence that the SHR strain may represent a useful genetic and pharmacological toot to investigate ethanol drinking traits. (c) 2005 Elsevier Inc. All rights reserved.