MORPHOLOGIC CHANGES IN THE LAMINA CRIBROSA CORRELATED WITH NEURAL LOSS IN OPEN-ANGLE GLAUCOMA
MORPHOLOGIC CHANGES IN THE LAMINA CRIBROSA CORRELATED WITH NEURAL LOSS IN OPEN-ANGLE GLAUCOMA
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DOI：
10.1016/0002-9394(83)90389-6
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发表时间：
1983-01-01
影响因子：
4.2
通讯作者：
GREEN, WR
中科院分区：
文献类型：
--
作者：
QUIGLEY, HA;HOHMAN, RM;GREEN, WR
根据视野测试或视神经纤维的剩余数量，将青光眼患者的眼睛（25只）分为3组，分别代表轻度（第1组，7只眼睛）、中度（第2组，11只眼睛）和重度（第3组，6只眼睛）视神经损伤。通过扫描电子显微镜检查每只眼的视神经乳头。连续筛板片的压缩是最早检测到的异常，发生在一些眼睛之前检测到视野损失。整个筛板的后弯是一个较晚的变化，并涉及其上，下极比中间的神经头。在这些成人青光眼眼中，Bruch膜水平处的巩膜开口直径没有扩大。机械压迫的神经头发生足够早，被认为是一个主要的发病事件在昏迷性损害。
Glaucomatous human eyes (25) were divided into 3 groups representing mild (group 1, 7 eyes), moderate (group 2, 11 eyes), and severe (group 3, 6 eyes) optic nerve damage, based on visual field testing or remaining number of optic nerve fibers. The optic nerve head of each eye was examined by scanning electron microscopy. Compression of the successive lamina cribrosa sheets was the earliest detected abnormality, occurring in some eyes before the detection of visual field loss. Backward bowing of the entire lamina cribrosa was a later change and involved its upper and lower poles more than the mid-nerve head. The diameter of the scleral opening at the level of Bruch''s membrane did not enlarge in these adult glaucomatous eyes. Mechanical compression of the nerve head occurred early enough to be considered a primary pathogenetic event in glaucomatous damage.