VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
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DOI：
10.1007/s12079-016-0352-8
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发表时间：
2016-12-01
影响因子：
4.1
通讯作者：
Sudhakaran, Perumana R.
中科院分区：
文献类型：
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作者：
Abhinand, Chandran S.;Raju, Rajesh;Sudhakaran, Perumana R.
血管内皮生长因子-A（VEGF-A）是血管生成相关的内皮细胞功能所必需的。由VEGF系统中最突出的配体-受体复合物VEGFA/VEGFR 2启动的信号转导网络导致参与血管生成的内皮细胞增殖、迁移、存活和新血管形成。考虑到其生物医学的重要性，我们已经开发了第一个全面的地图内皮细胞特异性信号事件的VEGFA/VEGFR 2系统有关血管生成。通过对20，000多篇已发表的研究文章进行筛选，并根据VEGFR 2的翻译后修饰（PTM）和位点特异性，我们记录了240种蛋白及其参与VEGFA/VEGFR 2信号转导的各种PTM依赖性反应。从配体-受体复合物，这张地图已被扩展到主要的转录调控基因的水平，导致其转录因子的信号级联的报告。我们相信，这张地图将作为一个新的平台，参考，整合和代表性，更重要的是，血管内皮细胞中的VEGF信号转导的动态特征，包括他们的交叉谈判与其他配体受体系统参与血管生成的渐进分析。
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis. Considering its biomedical importance, we have developed the first comprehensive map of endothelial cell specific signaling events of VEGFA/ VEGFR2 system pertaining to angiogenesis. Screening over 20,000 published research articles and following the post-translational modification (PTM) and site specificity of VEGFR2, we have documented 240 proteins and their diverse PTM-dependent reactions involved in VEGFA/ VEGFR2 signal transduction. From the ligand-receptor complex, this map has been extended to the level of major transcriptionally regulated genes for which the signaling cascades leading to their transcription factors are reported. We believe that this map would serve as a novel platform for reference, integration, and representation and more significantly, the progressive analysis of dynamic features of VEGF signaling in endothelial cells including their cross-talks with other ligand-receptor systems involved in angiogenesis.