Affective Control Training (AffeCT) reduces negative affect in depressed individuals.
Affective Control Training (AffeCT) reduces negative affect in depressed individuals.
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DOI：
10.1016/j.jad.2022.06.016
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发表时间：
2022-07
影响因子：
6.6
通讯作者：
S. Schweizer;T. Auer;C. Hitchcock;L. Lee-Carbon;Evangeline Rodrigues;T. Dalgleish
中科院分区：
文献类型：
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作者：
S. Schweizer;T. Auer;C. Hitchcock;L. Lee-Carbon;Evangeline Rodrigues;T. Dalgleish
抑郁症是全球残疾的主要原因，患病率不断上升。尽管问题规模很大，但可用的药理和心理干预措施的功效有限。国家卫生研究所的行为改变科学框架建议通过利用基础科学的见解来确定新干预措施可以针对的机制来解决这一问题。目前的研究评估了一个旨在改善情感控制的计算机程序的潜力，情感控制是一个涉及抑郁症风险和维持的机械目标。在第一阶段，48名抑郁症患者（平均年龄：39岁，75%为女性）的认知特征与16名从未抑郁过的患者（平均年龄：31岁，56%为女性）的认知功能进行了比较。诊断组之间不同的功能的唯一指数是反应时间在负和正valanced试验的情感Stroop任务（D= 0.58）。然后使用该指数来评估情感控制训练（AffeCT）与安慰剂训练的对比。结果显示，在第一阶段，与从未抑郁的个体相比，任务没有显着变化。然而，与安慰剂训练相比，AffeCT导致目标指数，情感Stroop表现（d= 1.17）的显着更大的改善。重要的是，与安慰剂训练相比，通过积极情绪和消极情绪时间表测量，AffeCT导致消极情绪的减少更大（d=0.98）。这项概念验证研究表明，AffeCT对抑郁症患者的影响有希望，但对抑郁症状没有好处。它进一步支持行为改变框架的科学的效用，强调在评估新的干预措施时需要确定有意义的靶机制测定。
Depression is the leading cause of disability worldwide, with prevalence rates rising. Despite the scale of the problem, available pharmacological and psychological interventions only have limited efficacy. The National Institute of Health's Science of Behaviour Change framework proposes to address this issue by capitalising on insights from basic science to identify mechanisms that can be targeted by novel interventions. The current study evaluated the potential of a computerized programme aimed at improving affective control, a mechanistic target involved in both risk and maintenance of depression. In a first phase the cognitive profiles of 48 depressed individuals (mean age: 39 years, 75 % female) were compared to cognitive functioning in 16 never-depressed individuals (mean age: 31 years, 56 % female). The sole index of functioning that differed between diagnostic groups was reaction time across negative and positively valanced trials on an affective Stroop task (d= 0.58). This index was then used to evaluate an affective control training (AffeCT) against a placebo training. Results showed no significant changes on tasks that showed no differences with never-depressed individuals in Phase I. However, compared to placebo training, AffeCT led to significantly greater improvement in the target index, affective Stroop performance (d= 1.17). Importantly, AffeCT led to greater reductions in negative affect as measured by the Positive Affect and Negative Affect Schedule compared to the placebo training (d=0.98). This proof-of-concept study shows promising benefits of AffeCT on depressed individuals' affect, but not depressive symptoms. It further supports the utility of the Science of Behaviour Change framework, highlighting the need for determining meaningful assays of target mechanisms when evaluating novel interventions.