EFFECT OF METAL CATIONS AND PH ON ANTIBACTERIAL ACTIVITY AND UPTAKE OF LONG-CHAIN FATTY-ACIDS
EFFECT OF METAL CATIONS AND PH ON ANTIBACTERIAL ACTIVITY AND UPTAKE OF LONG-CHAIN FATTY-ACIDS
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DOI：
10.1111/j.1365-2672.1973.tb04149.x
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
MILLER, TB
中科院分区：
文献类型：
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作者：
GALBRAITH, H;MILLER, TB
长链饱和脂肪酸的杀菌活性被碱土金属拮抗。亚油酸的活性被有效地拮抗，但更敏感的铁和亚锡离子的逆转。随着pH值的增加，月桂酸的杀菌活性降低，而长链饱和酸的杀菌活性增加。革兰氏阳性菌和革兰氏阴性菌都可逆地吸附脂肪酸。随着pH值的降低和链长的增加，吸收量增加。虽然吸附程度较小，但亚油酸的内在活性大于月桂酸。摄取似乎是非特异性的，并受酸和细菌细胞表面的物理化学性质的控制。对脂肪酸的敏感性随着pH值的降低而增加。巨大芽孢杆菌原生质体比全细胞更大程度地吸附脂肪酸。革兰氏阴性菜豆假单胞菌的耐药性不是由于脂肪酸的不吸附。
Summary.The bactericidal activity of long chain saturated fatty acids was antagonized by alkaline earth metals. The activity of linoleic acid was less effectively antagonized but was more sensitive to reversal by ferric and stannous ions. With increasing pH value the bactericidal activity of lauric acid decreased but that of the longer chain saturated acids increased. Both Gram positive and Gram negative bacteria reversibly adsorbed fatty acids. Uptake increased with decreasing pH value and increasing chain length. Although adsorbed to a lesser extent, the intrinsic activity of linoleic acid was greater than lauric acid. The uptake appeared to be non‐specific and governed by the physicochemical properties of both the acids and the bacterial cell surfaces. Sensitivity to the fatty acids increased with decreasing pH value. Protoplasts ofBacillus megateriumadsorbed fatty acids to a greater extent than whole cells. Resistance of the Gram negativePseudomonas phaseolicolawas not due to non‐adsorption of the fatty acids.