Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi.
Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi.
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两种疟疾寄生虫诺氏疟原虫菌株的环子孢子抗原基因的多样性。
DOI：
10.1126/science.4023712
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Godson,GN
中科院分区：
文献类型：
--
作者：
Sharma,S;Svec,P;Mitchell,GH;Godson,GN
报道了疟疾知识疟原虫努里株环子孢子抗原基因(CS基因)编码区的全序列。与H株的CS基因相比，Nuri株的CS基因呈现出一种新的序列多样性形式。与H毒株的12个串联重复的36个碱基对单位不同，努里毒株包含16个串联重复的27个碱基单位的不同核苷酸序列，编码不同的重复多肽。相反，重复序列两侧的5‘和3’编码和非编码序列在两个菌株中都有98%的保守性。
The complete nucleotide sequence of the coding region of the circumsporozoite antigen gene (CS gene) of the Nuri strain of the malarial parasitePlasmodium knowlesiis presented. The gene from the Nuri strain exhibits a novel form of sequence diversity when compared to the CS gene from the H strain. Instead of the 12 tandem repeating 36-base pair units of the H strain, the Nuri strain contains 16 tandem repeating 27-base pair units of a different nucleotide sequence that encodes a different repeating peptide. In contrast, the 5′ and 3′ coding and noncoding sequences flanking the repeats are 98 percent conserved in both strains.