A polymeric IgA response in serum can be produced by parenteral immunization.
A polymeric IgA response in serum can be produced by parenteral immunization.
复制标题
血清中的聚合IgA反应可以通过肠胃外免疫产生。
作者：
F. Mascart‐Lemone;J. Duchateau;Melissa N. Conley;D. Delacroix
在10名志愿者中，在前一次加强免疫后5-20年，用破伤风类毒素（TT）疫苗进行肠外刺激后，分析了血清特异性聚合（p-）和单体（m-）伊加抗体应答的幅度和动力学。一个快速显着的血清伊加抗体反应，涉及单体和聚合伊加组分的IgA观察：m-IgA和p-IgA抗体达到峰值血清活性在约11天，约6天前的IgG抗体活性的峰值。在伊加应答的峰值，p-IgA占抗TT活性的大约一半（中位数54%，25-79%）。然而，p-IgA抗体迅速从血清中消失了几个星期，而血清中的m-IgA抗体反应维持了很长一段时间。对于五分之一的受试者，还在唾液中检测到抗TT伊加，其活性峰值早于血清。计算白蛋白相对排泄系数的抗TT伊加在这个唾液中建议这些抗体的本地合成。本研究表明，血清中的多聚体伊加抗体反应可以通过肠外免疫在致敏个体中产生，这提出了控制多聚体与单体伊加产生的机制的问题。
The magnitude and the kinetics of the serum-specific polymeric (p-) and monomeric (m-) IgA antibody responses were analysed following parenteral stimulation with tetanus toxoid (TT) vaccine in 10 volunteers, 5-20 years after a previous boost. A rapid marked serum IgA antibody response involving both the monomeric and polymeric components of IgA was observed: m-IgA and p-IgA antibodies reached a peak of serum activity at about 11 days, around 6 days before the peak of IgG antibody activity. At the peak of the IgA response, p-IgA accounted for approximately half of the anti-TT activity (median 54%, 25-79%). However, p-IgA antibodies rapidly disappeared from serum over a few weeks, whereas the serum m-IgA antibody response was maintained over a prolonged period of time. For one subject out of five, anti-TT IgA were also detected in saliva with a peak of activity earlier than in serum. Calculation of the albumin relative coefficient of excretion for anti-TT IgA in this saliva suggested a local synthesis of these antibodies. The present study indicates that a polymeric IgA antibody response in serum can be produced by parenteral immunization in primed individuals, and it raises the question of the mechanisms that control polymeric versus monomeric IgA production.