Bioactive Meroterpenoids and Isocoumarins from the Mangrove Derived Fungus Penicillium sp. TGM112
Bioactive Meroterpenoids and Isocoumarins from the Mangrove Derived Fungus Penicillium sp. TGM112
复制标题
来自红树林衍生真菌青霉属的生物活性类萜和异香豆素。
DOI：
10.1021/acs.jnatprod.8b00866
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发表时间：
2019-05-01
影响因子：
5.1
通讯作者：
Chen, Guang-Ying
中科院分区：
文献类型：
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作者：
Bai, Meng;Zheng, Cai-Juan;Chen, Guang-Ying
从红树林真菌Penicillium sp. TGM 112中分离得到两个新的部分萜类化合物，penicianstinoids A和B（1和2），八个新的异香豆素类化合物，peniciisocoumarins A-H（3-10），以及10个已知的类似物（11-20）。1-10的结构和绝对构型通过详细的NMR、MS光谱数据、X射线衍射分析、改进的Mosher方法和计算的电子圆二色性数据的解释来确定。化合物1-4、7、8、10、12、13和16对棉铃虫（Helicoverpa armigera Hubner）初孵幼虫表现出生长抑制活性，IC 50值分别为50 - 200 μ g/mL。化合物1、2和11-15显示出对秀丽隐杆线虫的活性，其EC 50值分别为9.4（+/-1.0）至38.2（+/-0.6）μ g/mL。化合物1是本文第二次报道的类austinoid-like meroterpenoid，其中碳-碳双键在C-1 ′-C-2 ′处被氧化成羰基。
Two new meroterpenoids, penicianstinoids A and B (1 and 2), and eight new isocoumarins, peniciisocoumarins A-H (3-10), together with 10 known analogues (11-20) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. The structures and absolute configurations of 1-10 were determined by interpretation of detailed NMR, MS spectroscopic data, X-ray diffraction analyses, modified Mosher's method, and calculated electronic circular dichroism data. Compounds 1-4, 7, 8, 10, 12, 13, and 16 showed growth inhibition activity against newly hatched larvae of Helicoverpa armigera Hubner with IC50 values ranging from 50 to 200 mu g/mL, respectively. Compounds 1, 2, and 11-15 displayed activity against Caenorhabditis elegans with EC50 values ranging from 9.4 (+/- 1.0) to 38.2 (+/- 0.6) mu g/mL, respectively. Compound 1 represents an austinoid-like meroterpenoid that is reported here for the second time, in which a carbon-carbon double bond was oxidized to a carbonyl group at C-1'-C-2'.