Self-assembling amphiphilic siderophores from marine bacteria
Self-assembling amphiphilic siderophores from marine bacteria
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DOI：
10.1126/science.287.5456.1245
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发表时间：
2000-02-18
期刊：
影响因子：
56.9
通讯作者：
Butler, A
中科院分区：
文献类型：
--
作者：
Martinez, JS;Zhang, GP;Butler, A
大多数好氧细菌分泌铁载体，以促进铁的收购。从两个不同属的海洋细菌菌株中分离出两个铁载体家族。来自海水盐单胞菌菌株DS 40 M3的水裸藻素和来自海水藻属菌株DS 40 M6和DS 40 M8的marinobactins各自含有与铁（III）配位的独特肽头基和一系列脂肪酸部分之一的附属物。这些铁载体具有低临界胶束浓度（CMC）。在不存在铁的情况下，marinobactins以超过其CMC的浓度作为胶束存在;在加入铁（III）后，胶束发生自发相变以形成囊泡。这些观察结果表明，独特的铁获取机制可能已经在海洋细菌中进化。
Most aerobic bacteria secrete siderophores to facilitate iron acquisition. Two families of siderophores were isolated from strains belonging to two different genera of marine bacteria. The aquachelins, from Halomonas aquamarina strain DS40M3, and the marinobactins, from Marinobacter sp. strains DS40M6 and DS40M8, each contain a unique peptidic head group that coordinates iron(III) and an appendage of one of a series of fatty acid moieties. These siderophores have low critical micelle concentrations (CMCs). In the absence of iron, the marinobactins are present as micelles at concentrations exceeding their CMC; upon addition of iron(III), the micelles undergo a spontaneous phase change to form vesicles. These observations suggest that unique iron acquisition mechanisms may have evolved in marine bacteria.