Metabolic impact of obesity in childhood
Metabolic impact of obesity in childhood
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DOI：
10.1016/s0889-8529(05)70099-2
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发表时间：
1999-12-01
影响因子：
4.5
通讯作者：
Tamborlane, WV
中科院分区：
文献类型：
--
作者：
Caprio, S;Tamborlane, WV
儿童肥胖目前在美国是一个日益严重的问题。利用正常血糖-高胰岛素和高血糖钳夹技术沿着磁共振成像，作者研究了肥胖儿童体内葡萄糖和脂质代谢的变化及其与脂肪分布的关系。研究表明，内脏脂肪增加、高胰岛素血症和胰岛素抵抗是密切相关的异常，在肥胖的自然史早期表现出来。
Childhood obesity currently is a growing problem in the United States. Using the euglycemic-hyperinsulinemic and hyperglycemic clamp techniques along with magnetic resonance imaging, the authors examined changes in glucose and lipid metabolism in vivo and their relationship to fat distribution in obese children. The studies indicated that increased visceral fat, hyperinsulinemia, and insulin resistance are closely linked abnormalities that are expressed early in the natural history of obesity.