The homotopic connectivity of the functional brain: a meta-analytic approach
The homotopic connectivity of the functional brain: a meta-analytic approach
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DOI：
10.1038/s41598-019-40188-3
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发表时间：
2019-03-04
影响因子：
4.6
通讯作者：
Cauda, Franco
中科院分区：
文献类型：
--
作者：
Mancuso, Lorenzo;Costa, Tommaso;Cauda, Franco
同伦连接（HC）是大脑半球镜像区域之间的连接。它可以表现出明显的和功能相关的空间变异性，并可能受到几种病理条件的干扰。体素镜像同伦连接（VMHC）是一种基于静息状态功能连接来探究这种大脑组织模式的技术。由于功能连接也可以显示在一个元分析的方式使用共激活，在这里，我们建议计算的元分析同伦连接（MHC）作为元分析对应的VMHC。这两种技术之间的比较揭示了它们的一般相似性，但也突出了区域差异与HC如何从任务到休息。从休息到任务发现了两个主要差异：（i）已知以全局中心为特征的区域比显示局部中心的区域更相似;（ii）内侧区域的特征在于更高程度的同伦连接，而外侧区域似乎在任务执行期间降低了它们的同伦连接程度。这些发现表明，MHC可以成为一个有见地的工具，研究如何在任务和休息条件下的半球功能相互作用。
Homotopic connectivity (HC) is the connectivity between mirror areas of the brain hemispheres. It can exhibit a marked and functionally relevant spatial variability, and can be perturbed by several pathological conditions. The voxel-mirrored homotopic connectivity (VMHC) is a technique devised to enquire this pattern of brain organization, based on resting state functional connectivity. Since functional connectivity can be revealed also in a meta-analytical fashion using co-activations, here we propose to calculate the meta-analytic homotopic connectivity (MHC) as the meta-analytic counterpart of the VMHC. The comparison between the two techniques reveals their general similarity, but also highlights regional differences associated with how HC varies from task to rest. Two main differences were found from rest to task: (i) regions known to be characterized by global hubness are more similar than regions displaying local hubness; and (ii) medial areas are characterized by a higher degree of homotopic connectivity, while lateral areas appear to decrease their degree of homotopic connectivity during task performance. These findings show that MHC can be an insightful tool to study how the hemispheres functionally interact during task and rest conditions.