Association of body mass index changes from childhood to adulthood with dyslipidemia in adults: Hanzhong adolescent cohort study
Association of body mass index changes from childhood to adulthood with dyslipidemia in adults: Hanzhong adolescent cohort study
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儿童期至成年期体重指数变化与成人血脂异常的关系：汉中青少年队列研究。
DOI：
10.1093/pubmed/fdaa108
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发表时间：
2021-12-10
影响因子：
4.4
通讯作者：
Mu，Jian-Jun
中科院分区：
文献类型：
--
作者：
Liao，Yue-Yuan;Chu，Chao;Mu，Jian-Jun
研究背景血脂异常是一种脂质代谢紊乱，与胰岛素抵抗有关。纵向身体质量指数（BMI）的变化，从儿童到成年和长期血脂异常之间的关系进行了探讨，在本study.MethodsWe评估了纵向关系的BMI变化，因为儿童和血脂异常之间的1738名参与者在农村地区的汉中市，陕西。所有参与者于1987年在6至15岁之间进行了首次检查，并于1995年，2013年和2017年进行了复查;总随访时间为30年。结果从儿童期到成年期，正常体重逐渐发展为超重（OR = 1.65，95%CI = 1.27，2.15）或持续超重（OR = 2.45，95%CI = 1.52，3.96）与成年期血脂异常风险增加有关。如果儿童时期的超重或肥胖在成年后得到解决，这些风险基本上就消失了。成年后BMI越高，超重开始的年龄越小，血脂异常的风险越高。ConclusionsEarly weight loss和从童年到成年的任何程度的体重减轻都有助于改善成年后的血脂异常。我们进一步强调体重管理和控制在公共卫生初级预防中的重要性。
BackgroundDyslipidemia is a disorder of lipid metabolism and associated with insulin resistance. The relationship between longitudinal body mass index (BMI) changes from childhood to adulthood and long-term dyslipidemia was explored in this study.MethodsWe assessed the longitudinal relationship between BMI changes since childhood and dyslipidemia among 1738 participants in rural areas of Hanzhong City, Shaanxi. All participants were initially examined between the ages of 6 and 15 years in 1987 and were reexamined in 1995, 2013 and 2017; the total follow-up duration was 30 years. Anthropometric measurements and blood biochemistry indexes were measured.ResultsWe found that gradual progression of normal weight to overweight (OR = 1.65; 95% CI = 1.27, 2.15) or persistent overweight (OR = 2.45; 95% CI = 1.52, 3.96) from childhood to adulthood was associated with an increased risk of dyslipidemia in adulthood. And these risks were largely disappeared if the overweight or obesity during childhood was resolved by adulthood. The higher the BMI in adulthood and the younger the age at which overweight begins, the higher the risk of dyslipidemia.ConclusionsEarly weight loss and any degree of weight loss from childhood to adulthood can help improve dyslipidemia in adulthood. We further emphasize the importance of weight management and control in public health primary prevention.