Special K: once the fun is over an EMT arrives for the bladder.
Special K: once the fun is over an EMT arrives for the bladder.
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DOI：
10.1152/ajprenal.00239.2017
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
W. Hill;Weiqun Yu
中科院分区：
文献类型：
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作者：
W. Hill;Weiqun Yu
Wang等人报告称，在大鼠每日暴露于氯胺酮16周后，尿道上皮开始发生表型转化，变为更间充质状态。这种上皮向间质转化（EMT）具有几个经典的分子标志，Wang等人令人信服地证明，其中许多包括E-钙粘蛋白的下调、间质标志物波形蛋白和成纤维细胞特异性蛋白（FSP-1）的上调、上皮和间质标志物在尿路上皮相关细胞亚群中的共定位以及尿路上皮中TGFβ 1表达的上调。
Wang et al. report that in rats exposed to daily ketamine for sixteen weeks, the urothelium begins to undergo phenoconversion to a more mesenchymal state. This epithelial to mesenchymal transition (EMT), has several classic molecular hallmarks and Wang et al. demonstrate convincingly that a number of these including downregulation of E-cadherin, upregulation of mesenchymal markers vimentin and fibroblast specific protein (FSP-1), colocalization of both epithelial and mesenchymal markers in a subset of urothelium-associated cells and upregulation of TGFβ expression in urothelium are all present.