Long noncoding RNAs: p53's secret weapon in the fight against cancer?
Long noncoding RNAs: p53's secret weapon in the fight against cancer?
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DOI：
10.1371/journal.pbio.3000143
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发表时间：
2019-02-01
期刊：
影响因子：
9.8
通讯作者：
Lal, Ashish
中科院分区：
文献类型：
--
作者：
Dangelmaier, Emily;Lazar, Sarah B.;Lal, Ashish
p53调控着数百个基因的表达。最近令人惊讶的观察表明，没有单一的蛋白质编码基因控制p53的肿瘤抑制作用。这提出了一种可能性，即这些基因的一个子集，由p53诱导的长非编码RNA（lncRNA）调节，可以控制p53的肿瘤抑制功能。我们提出了lncRNA可以调节这一基因子集的分子机制，并假设lncRNA在p53基因组稳定性维持功能中具有令人兴奋的直接作用。探索这些机制可以揭示lncRNA作为p53不可或缺的介质，并为理解其他转录因子如何通过lncRNA发挥作用奠定基础。
p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53. This raises the possibility that a subset of these genes, regulated by a p53-induced long noncoding RNA (lncRNA), could control p53's tumor suppressor function. We propose molecular mechanisms through which lncRNAs could regulate this subset of genes and hypothesize an exciting, direct role of lncRNAs in p53's genome stability maintenance function. Exploring these mechanisms could reveal lncRNAs as indispensable mediators of p53 and lay the foundation for understanding how other transcription factors could act via lncRNAs.