Prechallenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain Hanks
Prechallenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain Hanks
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DOI：
10.1086/514634
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发表时间：
1998-07-01
影响因子：
11.8
通讯作者：
Gwaltney, JM
中科院分区：
文献类型：
--
作者：
Alper, CM;Doyle, WJ;Gwaltney, JM
这项双盲研究确定了血清中和抗体效价对成年志愿者实验性暴露于鼻病毒汉克斯株(RV-H)后感染率和疾病表现程度的影响。对133名健康志愿者进行了抗体状态检测，隔离6天，并在第一天结束时用RV-H进行攻击。在这些日子里，通过症状日记和体检来评估对病毒挑战的反应。低滴度感染组与中滴度感染组和未感染组在攻击后鼻咽部症状、排出分泌物重量、鼻腔粘液纤毛清除率和中耳负压频率方面均有显著差异。感染的高滴度组与低滴度组的比较也有类似的趋势。这些数据表明，高同型血清中和抗体效价与预防感染和减轻实验性RV-H暴露后的体征和症状有关。
This double-blind study determined the influence of serum neutralizing antibody titers on the rate of infection and magnitude of disease expression after experimental exposure of adult volunteers to rhinovirus strain Hanks (RV-H). A total of 133 healthy volunteers were tested for antibody status, cloistered for a 6-day period, and challenged with RV-H at the end of the first cloister day. On these days, response to viral challenge is assessed with symptom diaries and physical examinations. The low-titer infected group was significantly different from the intermediate-titer infected and the uninfected groups in terms of postchallenge nasal and throat symptoms, expelled secretion weights, nasal mucociliary clearance rates, and frequency of negative middle ear pressures. A similar trend held for the infected high-titer vs, low-titer group comparisons. These data show that high homotypic serum neutralizing antibody titers are associated with protection from infection and lessened signs and symptoms following experimental RV-H exposure.