Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study
Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study
复制标题
中国农村青光眼（中国青光眼农村流行病学（REG-China））：一项全国横断面研究
DOI：
10.1136/bjo-2021-320754
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发表时间：
2022-07-15
影响因子：
4.1
通讯作者：
Yan, Hua
中科院分区：
文献类型：
--
作者：
Liu, Yuanyuan;Yao, Baoqun;Yan, Hua
目的调查中国10个省农村人群青光眼患病率及其相关因素。设计：一项基于人群的横断面研究。方法对来自全国10个省市的6岁以上儿童进行视力检查、裂隙灯检查、检眼镜检查和非接触式眼压测量。青光眼可疑者行眼底照相、Goldmann压平眼压计、视野检查和前房角镜检查。根据国际地理和流行病学眼科学学会分类方案确定青光眼。使用多元逻辑回归模型评估人口统计学和医学因素与青光眼的关系。结果从2017年6月到2018年10月，52041名参与者中有48398人被纳入最终分析。在6岁以上的参与者中，青光眼的年龄标准化患病率为1.7%（95% CI 1.55%至1.78%），在40岁以上的参与者中为2.1%（95% CI 1.93%至2.23%）。青光眼的构成比为：原发性闭角型青光眼（PACG）44.4%，原发性开角型青光眼34.7%，先天性青光眼2.6%，其他类型青光眼18.3%。年龄增长、吸烟、脑卒中、2型糖尿病、高等教育（大专以上）和较高的个人收入是PACG的重要危险因素。整个研究人群的单侧和双侧失明率分别为4.692%和1.068%。青光眼家族史是至少一只眼睛患青光眼和失明的重要危险因素。结论农村人群青光眼患病率较高，应将其纳入中国慢性病管理项目进行长期护理。
Objective This study aimed to investigate the prevalence of glaucoma with associated factors in the rural populations of 10 provinces in China. Design A population-based cross-sectional study. Methods All participants aged 6 years or older from 10 provinces completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography, Goldmann applanation tonometry, visual field testing and gonioscopy. Glaucoma was determined according to the International Society of Geographical and Epidemiological Ophthalmology classification scheme. Associations of demographics and medical factors with glaucoma were assessed using multiple logistic regression models. Results From June 2017 to October 2018, 48 398 of 52 041 participants were included in the final analyses. The age-standardised prevalence of glaucoma was 1.7% (95% CI 1.55% to 1.78%) among the participants older than 6 years, which was 2.1% (95% CI 1.93% to 2.23%) in participants aged over 40 years. The constituent ratios of glaucoma were: 44.4% primary angle-closure glaucoma (PACG), 34.7% primary open-angle glaucoma, 2.6% congenital glaucoma and 18.3% other types of glaucoma. Increasing age, smoking, cerebral stroke, type 2 diabetes, higher education (college or more) and higher personal income were significant risk factors for PACG. The unilateral and bilateral blindness rates in the entire study population were 4.692% and 1.068%, respectively. A family history of glaucoma was a significant risk factor for the prevalence of glaucoma and blindness in at least one eye. Conclusions Rural populations have a high prevalence of glaucoma, which should be included in chronic disease management programmes in China for long-term care.