Temporal Dynamics of Transdermal Alcohol Concentration Measured via New-Generation Wrist-Worn Biosensor
Temporal Dynamics of Transdermal Alcohol Concentration Measured via New-Generation Wrist-Worn Biosensor
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DOI：
10.1111/acer.14172
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发表时间：
2019-08-30
影响因子：
3.2
通讯作者：
Kang, Dahyeon
中科院分区：
文献类型：
--
作者：
Fairbairn, Catharine E.;Kang, Dahyeon
背景：经皮酒精生物传感器的发展可能代表着在遏制有问题的饮酒方面取得的巨大进步。但有几个因素限制了现有透皮技术的实用性，包括血液酒精浓度(BAC)和透皮酒精浓度(TAC)之间的相对较长的延迟，以及当前可用的透皮传感器(例如脚踝监测器)的大型/笨重设计。目前的研究使用BACTrack Skyn的原型测试了BAC和TAC之间的滞后时间。BACTrack Skyn是一种新一代腕式经皮传感器，具有紧凑的设计和智能手机集成的特点。方法受试者(N=30)在实验室接受一定剂量的酒精(目标BAC0.08%)或非酒精饮料，同时佩戴AMS SCRAM踝关节监测器和Skyn原型。参与者在实验室中接受监测，直到呼气酒精浓度(Brc)降至0.025以下。结果SKYN原型器件故障率(18%~38%)高于非原型SCRAM器件故障率(2%)。在有可用数据的参与者中，Skyn和SCRAM测量的TAC都显示出与brc的强烈相关性，并且Skyn和SCRAM设备在第一次饮酒后30分钟内都检测到了酒精。SKYN测量的TAC比SCRAM测量的TAC早一个多小时达到峰值(分别在峰值BRAC之后54分钟和120分钟)，时间序列模型表明，在所有BRAC曲线的测量部分中，平均而言，Skyn TAC落后于BRAC 24分钟，而SCRAM TAC落后BRAC 69分钟--在P<；0.001，所有差异都具有统计学意义。结论研究结果为新一代腕式透皮传感器在受控实验室条件下的有效性提供了初步证据，并进一步表明该传感器具有良好的性能，因为它们与经皮酒精检测的潜伏期有关。与SCRAM相比，这里使用的SKYN原型版本显示出更高的故障率，未来将需要更可靠和坚固的SKYN原型，适合在不同环境条件下进行现场测试。
Background The development of a transdermal alcohol biosensor could represent a tremendous advance toward curbing problematic drinking. But several factors limit the usefulness of extant transdermal technology, including relatively lengthy delays between blood alcohol concentration (BAC) and transdermal alcohol concentration (TAC), as well as the large/bulky designs of currently available transdermal sensors (e.g., ankle monitors). The current research examined the lag time between BAC and TAC using a prototype of BACtrack Skyn-a new-generation wrist-worn transdermal sensor featuring a compact design and smartphone integration. Methods Participants (N = 30) received either a dose of alcohol (target BAC 0.08%) or a nonalcoholic beverage in the laboratory while wearing both the AMS SCRAM ankle monitor and a Skyn prototype. Participants were monitored in the laboratory until breath alcohol concentration (BrAC) dropped below 0.025%. Results Device failure rates for Skyn prototypes were relatively high (18 to 38%) compared with nonprototype SCRAM devices (2%). Among participants with usable data, both Skyn- and SCRAM-measured TAC showed strong correlations with BrAC, and both Skyn and SCRAM devices detected alcohol within 30 minutes of first alcohol administration. Skyn-measured TAC peaked over 1 hour earlier than SCRAM-measured TAC (54 versus 120 minutes after peak BrAC, respectively), and time-series models suggested that, on average across all measured portions of the BrAC curve, Skyn TAC lagged behind BrAC by 24 minutes, whereas SCRAM TAC lagged behind BrAC by 69 minutes-all differences statistically significant at p < 0.001. Conclusions Results provide preliminary evidence for the validity of a new-generation wrist-worn transdermal sensor under controlled laboratory conditions and further suggest favorable properties of this sensor as they pertain to the latency of transdermal alcohol detection. The prototype version of Skyn employed here displayed a higher failure rate compared with SCRAM, and, in future, more reliable and robust Skyn prototypes will be required suitable to field testing across diverse environmental conditions.