DIHYDROMONACOLIN-L AND MONACOLIN-X, NEW METABOLITES THOSE INHIBIT CHOLESTEROL-BIOSYNTHESIS
DIHYDROMONACOLIN-L AND MONACOLIN-X, NEW METABOLITES THOSE INHIBIT CHOLESTEROL-BIOSYNTHESIS
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DOI：
10.7164/antibiotics.38.321
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
MASUDA, M
中科院分区：
文献类型：
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作者：
ENDO, A;HASUMI, K;MASUDA, M
从橡胶红曲霉突变体培养物中分离出与monacolin K（一种有效的胆固醇生物合成抑制剂）结构相关的monacolin L和monacolin X。这两种代谢物的结构是通过物理技术的组合来确定的。还给出了二氢莫那可林L和莫那可林X作为羟甲基戊二酰辅酶a还原酶和体外固醇生物合成抑制剂的数据。
Dihydromonacolin L and monacolin X, which are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these 2 metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.