Neonatal handling alters brain organization but does not influence recovery from perinatal cortical injury
Neonatal handling alters brain organization but does not influence recovery from perinatal cortical injury
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DOI：
10.1037/0735-7044.119.5.1375
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发表时间：
2005-10-01
影响因子：
1.9
通讯作者：
Kolb, B
中科院分区：
文献类型：
--
作者：
Gibb, R;Kolb, B
研究表明，在断奶前将幼鼠从巢中移走会影响大脑和行为发育。作者假设，处理围产期（第4天）切除内侧额叶皮质的大鼠可能会减轻行为缺陷，并逆转与这种损伤相关的树突萎缩。术后第1天，将幼崽从窝中取出15分钟，每天3次，直至断奶。动物成年后接受莫里斯水任务和熟练伸手测试。被处理过的动物在行为表现上没有任何改善。处理过程导致顶叶皮层树突长度减少，但脊柱密度不变。脑损伤大鼠断奶前处理无治疗优势。
Handling rat pups by removing them from the nest during the preweaning period has been shown to influence brain and behavioral development. The authors hypothesized that handling rats with perinatal (Day 4) medial frontal cortex removals might attenuate behavioral deficits and reverse dendritic atrophy associated with such an injury. On the day after surgery, pups were removed from the nest for 15 min, 3 times per day until weaning. Animals were tested as adults in the Morris water task and on skilled reaching. Handled animals showed no improvement in behavioral performance. The handling procedure led to a decrease in dendritic length in parietal cortex, but spine density was unchanged. No therapeutic advantage was observed following the preweaning handling of brain-injured rats.