Design and evaluation of matrix type and membrane controlled transdermal delivery systems of nicotine suitable for use in smoking cessation
Design and evaluation of matrix type and membrane controlled transdermal delivery systems of nicotine suitable for use in smoking cessation
复制标题
适用于戒烟的尼古丁基质型和膜控透皮给药系统的设计和评估
DOI：
10.4103/0250-474x.25711
复制
发表时间：
2006
影响因子：
0.5
通讯作者：
N. Udupa
中科院分区：
文献类型：
--
作者：
S. Lewis;S. Pandey;N. Udupa
在印度，尼古丁替代疗法的供应量很低，因为只有少数进口商。目前，可忽略不计的形式的透皮贴剂，它们是昂贵的，不容易获得的普通man.In这项研究中，试图开发尼古丁的透皮贴剂，这是具有成本效益的，有利于印度市场。制备了两种类型的贴剂，单层和双层。单层膜片上有一层速率控制膜，而双层膜片则为基质型.通过标准技术评价贴剂的物理特性。发现贴剂中的药物含量均匀。透皮贴剂的体外释放研究显示了一种双相释放模式，对于基质类型，扩散是药物释放的主要机制，而膜控制释放尼古丁，在24 h的研究中逐渐释放。
The availability of nicotine-replacement therapies is very low in India, as there are only a few importers. Currently, negligible forms of transdermal patches are available, they are expensive, and not easily accessible to the common man. In this study, an attempt was made to develop transdermal patches of nicotine, which are cost effective and conducive to the Indian market. Two types of patches, monolayered and bilayered, were prepared. The monolayered patch bore a rate- controlling membrane, whereas the bilayered, served as matrix type. The physical charecteristics of the patches were evaluated by standard techniques. The drug content was found to be uniform in the patches. In vitro release studies of transdermal patches showed a biphasic release pattern, with diffusion as the dominating mechanism of drug release for the matrix type, while the membrane-controlled released nicotine, gradually over the 24 h study.