The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light
The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light
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DOI：
10.3109/07420529808998671
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发表时间：
1998-01-01
影响因子：
2.8
通讯作者：
Sack, RL
中科院分区：
文献类型：
--
作者：
Lewy, AJ;Bauer, VK;Sack, RL
褪黑激素的计时功能无疑与它主要在夜间黑暗中产生的事实有关;也就是说，褪黑激素和光线发生在相反的时间。人对褪黑激素的相位响应曲线（PRC）似乎与PRC对光的相位相差约12小时。这些惊人的互补性，加上光的急性抑制褪黑激素的产生，表明内源性褪黑激素的功能是增加夹带的昼夜节律起搏器的光暗周期。褪黑激素PRC还指示使用外源性褪黑激素治疗昼夜节律相位障碍的正确施用时间。
Melatonin's timekeeping function is undoubtedly related to the fact that it is primarily produced during nighttime darkness; that is, melatonin and light occur at opposite times. The human phase response curve (PRC) to melatonin appears to be about 12h out of phase with the PRC to light. These striking complementarities, together with light's acute suppressant effect on melatonin production, suggest that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle. The melatonin PRC also indicates correct administration times for using exogenous melatonin to treat circadian phase disorders.