Quantitative assessment of muscle echogenicity in Charcot-Marie-Tooth disease type 1A by automatic thresholding methods
Quantitative assessment of muscle echogenicity in Charcot-Marie-Tooth disease type 1A by automatic thresholding methods
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DOI：
10.1016/j.clinph.2021.05.030
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发表时间：
2021-09-22
影响因子：
4.7
通讯作者：
Nakagawa, Masanori
中科院分区：
文献类型：
--
作者：
Kitaoji, Takamasa;Noto, Yu-ichi;Nakagawa, Masanori
目的：探讨自动阈值法定量肌肉回声评估作为腓骨肌萎缩症1A型（CMT1A）疾病严重程度标志的实用性。方法：对15例CMT1A患者和7例健康对照者进行肌肉超声检查。采用16种自动阈值法和常规灰度分析法对每例受试者6块肢体肌肉的肌肉回声进行评估。将CMT1A患者和对照组的回声强度进行比较。还分析了CMT1A患者的回声强度与CMT神经病变评分（CMTNS）之间的相关性。结果如下：CMT1A患者和对照组之间6块肌肉的平均回声强度在灰度分析（p < 0.01）和16种自动阈值方法中的11种（每种方法p < 0.05）中均存在显著差异。在CMT1A患者中，在16种自动阈值方法中的8种方法中，6种肌肉的平均回声强度与CMTNS呈正相关，但在灰度分析中不相关。结论：自动阈值法可用于检测CMT1A患者和对照组之间肌肉回声的差异。回声参数与疾病严重程度相关。重要性：通过自动阈值方法进行的定量肌肉回声评估显示出作为CMT1A疾病进展的替代标志物的潜力。(c)2021国际临床神经生理学联合会。由Elsevier B.V.出版，版权所有。
Objective: To investigate the utility of automatic thresholding methods for quantitative muscle echogenicity assessment as a marker of disease severity in Charcot-Marie-Tooth disease type 1A (CMT1A). Methods: Muscle ultrasound was performed in 15 CMT1A patients and 7 healthy controls. Muscle echogenicity of six limb muscles in each subject was assessed by 16 automatic thresholding methods and conventional grey-scale analysis. Echogenicity of each method in CMT1A patients was compared with that in controls. A correlation between the echogenicity and CMT neuropathy score (CMTNS) was also analysed in CMT1A patients. Results: Significant differences in mean echogenicity of the 6 muscles between CMT1A patients and controls were found both in grey-scale analysis (p < 0.01) and 11 of the 16 automatic thresholding methods (p < 0.05 in each method). In CMT1A patients, mean echogenicity of the 6 muscles was positively correlated with CMTNS in 8 of the 16 automatic thresholding methods, but not in grey-scale analysis. Conclusion: Automatic thresholding methods can be used to detect the difference in muscle echogenicity between CMT1A patients and controls. Echogenicity parameters correlate with the disease severity. Significance: Quantitative muscle echogenicity assessment by automatic thresholding methods shows potential as a surrogate marker of disease progression in CMT1A. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.