Casual serum triglyceride as a predictor of premature type 2 diabetes mellitus: an 8-year cohort study of middle-aged Japanese workers
Casual serum triglyceride as a predictor of premature type 2 diabetes mellitus: an 8-year cohort study of middle-aged Japanese workers
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休闲血清甘油三酯作为早发 2 型糖尿病的预测因子：一项针对日本中年工人的 8 年队列研究
DOI：
10.1007/s13340-015-0241-z
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发表时间：
2016
影响因子：
2.2
通讯作者：
Miyamatsu N
中科院分区：
文献类型：
--
作者：
Nishikawa T;Okamura T;Shima A;Kawatsu S;Sugiyama D;Kadota A;Morimoto A;Tatsumi Y;Godai K;Miyamatsu N
BackgroundThe效用的临时血清甘油三酯（TG）作为预测2型糖尿病（DM）是不清楚的，特别是在最富有成效的years.MethodsParticipants是3271工人（913名男性和2358名女性，年龄20-57）没有DM在基线。他们连续8年接受年度体检。通过根据基线时的偶然血清TG水平将参与者分为4组来确定新诊断的DM与偶然血清TG水平之间的关联：低于50 mg/dL（A组）、50-100 mg/dL（B组）、100-150 mg/dL（C组）和≥150 mg/dL（D组）。随机血清TG水平与性别、肥胖或血糖水平对新诊断DM的影响也进行了评估。ResultsA共222例新诊断的2型DM患者，平均年龄50岁，在随访期间观察，即，A组10/406，B组66/1534，C组58/712，D组88/619。与A组相比，新诊断的DM（调整DM相关因素后）的比值比（OR）随着偶然血清TG水平的增加而增加：B组为1.38，C组为1.79，D组为2.36。此外，新诊断的糖尿病的OR是较高的参与者高偶然血清甘油三酯水平也是男性（OR 2.46），肥胖（OR 4.18），或有一个高血糖水平（OR 6.96）比在参考group.ConclusionsSerum TG水平≥150 mg/dL空腹或nonfasting是一个显着的预测2型糖尿病的中年日本工人。
BackgroundThe utility of casual serum triglyceride (TG) as a predictor of type 2 diabetes mellitus (DM) is unclear, especially during the most productive years.MethodsParticipants were 3271 workers (913 men and 2358 women, age 20–57) without DM at baseline. They underwent consecutive annual medical check-ups for 8 years. The association between newly diagnosed DM and casual serum TG level was determined by classifying the participants into 4 groups according to casual serum TG level at baseline: below 50 mg/dL (group A), 50–100 mg/dL (group B), 100–150 mg/dL (group C), and ≥150 mg/dL (group D). The effects of casual serum TG level in combination with sex, obesity, or serum glucose level on newly diagnosed DM were also evaluated.ResultsA total of 222 newly diagnosed type 2 DM cases with a mean age of 50 years old were observed during the follow-up period, i.e., 10/406 in group A, 66/1534 in group B, 58/712 in group C, and 88/619 in group D. Compared with group A, the odds ratio (ORs) for newly diagnosed DM (after adjusting for DM-associated factors) was found to increase with casual serum TG level: 1.38 (group B), 1.79 (group C), and 2.36 (group D). Moreover, the OR for newly diagnosed DM was higher in participants with high casual serum TG levels who were also male (OR 2.46), obese (OR 4.18), or had a high serum glucose level (OR 6.96) than in the reference group.ConclusionsSerum TG level ≥150 mg/dL when fasting or nonfasting is a significant predictor of type 2 diabetes in middle-aged Japanese workers.