Extra-Hippocampal Subcortical Limbic Involvement Predicts Episodic Recall Performance in Multiple Sclerosis
Extra-Hippocampal Subcortical Limbic Involvement Predicts Episodic Recall Performance in Multiple Sclerosis
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DOI：
10.1371/journal.pone.0044942
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发表时间：
2012-10-08
期刊：
影响因子：
3.7
通讯作者：
Auer, Dorothee P.
中科院分区：
文献类型：
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作者：
Dineen, Robert A.;Bradshaw, Christopher M.;Auer, Dorothee P.
背景：情节记忆障碍是多发性硬化症(MS)中一种常见但知之甚少的现象。我们的目的是利用定量神经成像来确定MS患者扩展的海马-间脑系统各部分完整性降低对记忆能力的相对贡献。方法/主要发现：34例复发-缓解期MS患者和24名年龄匹配的健康对照组进行了3T磁共振成像，包括扩散张量成像和三维T1加权体积采集。使用手动穹隆感兴趣区来推导穹隆分数各向异性(FA)。通过手工分割得到归一化的海马体、乳头体和丘脑体积。对MS受试者进行视觉回忆、言语回忆、言语再认和言语流畅性评估。经年龄和穹隆体积校正后，MS组穹隆FA与对照组比较有显著差异(0.38比0.46，P
Background: Episodic memory impairment is a common but poorly-understood phenomenon in multiple sclerosis (MS). We aim to establish the relative contributions of reduced integrity of components of the extended hippocampal-diencephalic system to memory performance in MS patients using quantitative neuroimaging.Methodology/Principal Findings: 34 patients with relapsing-remitting MS and 24 healthy age-matched controls underwent 3 T MRI including diffusion tensor imaging and 3-D T1-weighted volume acquisition. Manual fornix regions-of-interest were used to derive fornix fractional anisotropy (FA). Normalized hippocampal, mammillary body and thalamic volumes were derived by manual segmentation. MS subjects underwent visual recall, verbal recall, verbal recognition and verbal fluency assessment. Significant differences between MS patients and controls were found for fornix FA (0.38 vs. 0.46, means adjusted for age and fornix volume, P