Tenascin-C and the development of articular cartilage
Tenascin-C and the development of articular cartilage
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DOI：
10.1016/s0945-053x(05)80011-3
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发表时间：
1995-12-01
期刊：
影响因子：
6.9
通讯作者：
Pacifici, M
中科院分区：
文献类型：
--
作者：
Pacifici, M
与关于关节软骨结构和功能的大量文献相比，关于关节软骨在胚胎发生期间如何形成并被赋予独特的表型特性的知识相对较少，最值得注意的是在整个出生后生活中持续存在和发挥作用的能力。在这篇小综述中，我们总结了我们实验室最近的研究表明，细胞外基质蛋白腱生蛋白-C参与关节软骨细胞的发生和功能。这些和其他数据使我们提出生腱蛋白-C可能是体内机制的一部分，由此关节软骨细胞在长骨模型的骨骺处发育，在整个出生后生命中保持功能，并避免由位于骨骼模型的干骺端和骨干中的大量软骨细胞进行的软骨内骨化过程。
In comparison to the vast literature on articular cartilage structure and function, relatively little is known about how articular cartilage forms during embryo-genesis and is endowed with unique phenotypic properties, most notably the ability to persist and function throughout postnatal life. In this minireview, we summarize recent studies from our laboratory suggesting that the extracellular matrix protein tenascin-C is involved in the genesis and function of articular chondrocytes. These and other data have led us to propose that tenascin-C may be part of in vivo mechanisms whereby articular chondrocytes develop at the epiphysis of long bone models, remain functional throughout postnatal life, and avoid the endochondral ossification process undertaken by the bulk of chondrocytes located in the metaphysis and diaphysis of skeletal models.