Eating habits and risk of esophageal cancers: a population-based case-control study
Eating habits and risk of esophageal cancers: a population-based case-control study
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DOI：
10.1007/s10552-010-9576-8
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发表时间：
2010-09-01
影响因子：
2.3
通讯作者：
van der Pols, Jolieke C.
中科院分区：
文献类型：
--
作者：
Ibiebele, Torukiri I.;Taylor, Adele R.;van der Pols, Jolieke C.
目的饮食行为，如进食的时间、速度、经常饮用热饮、油炸、辛辣或烧烤食物可能与食管癌的风险增加有关。方法采用自填式问卷收集人口学、社会经济学和生活方式特征的数据，并采用食物频率问卷收集1,472例对照组、286例食管腺癌患者、240例食管癌患者的饮食行为数据。食管胃结合部腺癌（EGJAC）320例，食管鳞癌（ESCC）238例。我们计算比值比（OR）和95%的置信区间（CI）使用无条件的多变量调整logistic回归，调整混杂因素。结果频率的热饮，家庭油炸食品，烤肉，辛辣食品，吃晚餐的时间与食管癌的风险。经常食用油炸“外卖”食品的人患EGJAC的风险增加（OR = 1.44，95%CI = 1.01-2.05; p值= 0.04）。进食速度与ESCC风险呈负相关（趋势p = 0.001）。结论我们没有发现任何证据表明热饮、烤肉、辛辣食物或晚餐时间的摄入与食道癌风险增加有关在澳大利亚人群中。油炸“外卖”食品的消费量与进食速度之间的关系有待于未来的研究证实。
Objective Eating behaviors, such as the timing, speed of eating, and frequently consuming hot drinks, fried, spicy, or barbecued foods may be associated with increased risks of esophageal cancer. We analyzed data from a population-based case-control study to examine whether eating behaviors are associated with risk of esophageal cancer.Methods Self-administered questionnaire was used to collect data on demographic, socioeconomic, and lifestyle characteristics, and a food frequency questionnaire was used to collect data on dietary behaviors from 1,472 control subjects, 286 cases with adenocarcinoma of the esophagus, 320 cases with esophagogastric junction adenocarcinoma (EGJAC), and 238 cases with esophageal squamous cell carcinoma (ESCC). We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional multivariable adjusted logistic regression, adjusting for confounders.Results Frequency of hot drinks, home-fried foods, barbecued meats, spicy foods, and the timing of eating an evening meal were not associated with esophageal cancer risk. Those who frequently consumed fried 'take-away' food had increased risks of EGJAC (OR = 1.44, 95% CI = 1.01-2.05; p value = 0.04). Eating speed was inversely associated with ESCC risk (p for trend = 0.001).Conclusion We found no evidence that consumption of hot drinks, barbecued meats, spicy foods, or the timing of the evening meal are associated with increased risk of esophageal cancer in this Australian population. Associations with consumption of fried 'take-away' foods and eating speed await confirmation in future studies.