Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio
Circulating interferon-γ correlates with 1,25(OH)D and the 1,25(OH)D-to-25(OH)D ratio
复制标题
DOI：
10.1016/j.cyto.2012.05.015
复制
发表时间：
2012-10-01
期刊：
影响因子：
3.8
通讯作者：
Hill, Harry R.
中科院分区：
文献类型：
--
作者：
Barker, Tyler;Martins, Thomas B.;Hill, Harry R.
导致维生素D状态下降的机制（即，血浆或血清25-羟基维生素D（25（OH）D）浓度）在人类中是未知的。干扰素（IFN）-γ是一种炎症细胞因子，在分离的免疫细胞中调节维生素D代谢，但缺乏表明这种调节存在于体内的数据。因此，本研究的目的是将前交叉韧带（ACL）重建后恢复的年轻人在炎症应激期间循环IFN-γ扰动与25（OH）D和1，25-二羟维生素D（1，25（OH）D）变化联系起来。从12名男性患者术前和术后90个月、3天和7天的空腹抽血样本中测量血浆25（OH）D、1，25（OH）D和IFN-γ浓度。25（OH）D显著降低（p
The mechanism responsible for the decrease in vitamin D status (i.e., plasma or serum 25-hydroxyvitamin D (25(OH)D) concentration) during inflammatory stress is unknown in humans. Interferon (IFN)-gamma is an inflammatory cytokine that regulates vitamin D metabolism in isolated immune cells, but data suggesting this regulation exists in vivo is lacking. The purpose of this study, therefore, was to associate circulating IFN-gamma perturbations with 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)D) alterations during inflammatory stress in young adults recovering from anterior cruciate ligament (ACL) reconstruction. Plasma 25(OH)D, 1,25(OH)D and IFN-gamma concentrations were measured in fasting blood draw samples obtained from twelve-male patients pre-surgery and 90-m, 3-d and 7-d post-surgery. 25(OH)D decreased significantly (p