Progesterone regulation of primordial follicle assembly in bovine fetal ovaries.
Progesterone regulation of primordial follicle assembly in bovine fetal ovaries.
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DOI：
10.1016/j.mce.2009.09.004
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发表时间：
2009-12-10
影响因子：
4.1
通讯作者：
Skinner, Michael K.
中科院分区：
文献类型：
--
作者：
Nilsson, Eric E.;Skinner, Michael K.
Fertility in mammals is dependant on females having an adequate primordial follicle pool to supply oocytes for fertilization. The formation of primordial follicles is called ovarian follicular assembly. In rats and mice progesterone and estradiol have been shown to inhibit follicle assembly with assembly occurring after birth when the pups are removed from the high-steroid maternal environment. In contrast, primordial follicle assembly in other species, such as cattle and humans, occurs during fetal development before birth. The objective of the current study is to determine if progesterone levels regulate primordial follicle assembly in fetal bovine ovaries. Ovaries and blood were collected from bovine fetuses. Interestingly, ovarian progesterone and estradiol concentrations were found to decrease with increasing fetal age and correlated to increased primordial follicle assembly. Microarray analysis of fetal ovary RNA suggests that progesterone membrane receptor and estrogen nuclear receptor are expressed. Treatment of fetal bovine ovary cultures with a higher progesterone concentration significantly decreased primordial follicle assembly. Observations indicate that progesterone affects ovarian primordial follicle assembly in cattle, as it does in rats and mice.
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影响因子：
4.8
作者：
Kezele, P;Skinner, MK
通讯作者：
Skinner, MK
影响因子：
4.8
作者：
DUCSAY, CA;STANCZYK, FZ;NOVY, MJ
通讯作者：
NOVY, MJ
DOI：
10.1530/jrf.0.0110097
发表时间：
1966-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
ERICKSON, BH
通讯作者：
ERICKSON, BH
影响因子：
4.1
作者：
Juengel, JL;Sawyer, HR;McNatty, KP
通讯作者：
McNatty, KP
DOI：
10.1530/jrf.0.1140131
发表时间：
1998-09-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
Lun, S;Smith, P;McNatty, KP
通讯作者：
McNatty, KP