Impact of increased overweight on the projected prevalence of osteoporosis in older women
Impact of increased overweight on the projected prevalence of osteoporosis in older women
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DOI：
10.1007/s00198-006-0241-8
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发表时间：
2007-03-01
影响因子：
4
通讯作者：
Melton, L. J., III
中科院分区：
文献类型：
--
作者：
Looker, A. C.;Flegal, K. M.;Melton, L. J., III
超重在世界范围内不断增加，特别是在美利坚合众国。较高的体重与较高的骨密度，所以我们的目标是估计是否超重的患病率较高，可能会减少骨质疏松症的老年women.Methods我们计算了骨质疏松症的患病率的体重状况在老年妇女使用的数据从第三次全国健康和营养调查（NHANES III，1988-94）。我们将超重定义为体重指数（BMI）≥ 25，将骨质疏松定义为股骨颈骨矿物质密度（BMD）值低于年轻女性平均值2.5个标准差或更多。为了估计骨质疏松症的预期患病率，我们将NHANES III中按体重状态划分的骨质疏松症患病率与NHANES 1999 - 2002中相应的体重状态患病率相比较。结果1999-2002年NHANES中68%的老年妇女超重，而NHANES III中62%的老年妇女超重。超重状况与骨质疏松患病率显著相关（P < 0.001）。然而，在NHANES 1999-2002年骨质疏松症的预期患病率仅略低于NHANES III（16.8%与18.1%，分别）。结论超重的老年美国妇女的患病率增加似乎不太可能伴随着骨质疏松症的显着减少。
Introduction Overweight is increasing worldwide, but particularly in the United States of America. Higher body weight is associated with higher bone density, so our goal was to estimate whether the higher prevalence of overweight is likely to reduce osteoporosis among older women.Methods We calculated the prevalence of osteoporosis by weight status in older women using data from the third National Health and Nutrition Examination Survey (NHANES III, 1988-94). We defined overweight as a body mass index (BMI)>= 25 and osteoporosis as a femur neck bone mineral density (BMD) value 2.5 standard deviations or more below the mean of that of young women. To estimate the expected prevalence of osteoporosis, we applied the prevalence of osteoporosis by weight status from NHANES III to the corresponding weight status prevalence from NHANES 1999-2002.Results Of older women in NHANES 1999-2002, 68% were overweight compared to 62% in NHANES III. Overweight status was significantly related to osteoporosis prevalence (P < 0.001). However, the expected prevalence of osteoporosis in NHANES 1999-2002 was only slightly lower than that seen in NHANES III (16.8% vs 18.1%, respectively).Conclusions The increasing prevalence of overweight among older US women appears unlikely to be accompanied by a significant reduction in osteoporosis.