SCHWANN-CELL MULTIPLICATION IN TREMBLER MICE
SCHWANN-CELL MULTIPLICATION IN TREMBLER MICE
复制标题
DOI：
10.1111/j.1365-2990.1981.tb00081.x
复制
发表时间：
1981-01-01
影响因子：
5
通讯作者：
BRAY, GM
中科院分区：
文献类型：
--
作者：
PERKINS, CS;AGUAYO, AJ;BRAY, GM
突变小鼠Trembler的周围神经以严重的髓鞘缺损和雪旺细胞数量增加为特征。根据放射自显影和定量形态学调查，研究证明：出生后雪旺细胞在震颤鼠神经中增殖的异常持续性，在未受影响的动物中，神经由髓鞘纤维组成；Trembler小鼠无髓鞘（Remak）纤维中雪旺细胞的形态、数量和增殖正常；将震颤神经节段移植到正常小鼠的坐骨神经中，可增加雪旺细胞增殖率和髓磷脂缺陷。Trembler Schwann细胞的持续增殖一定与这些细胞无法产生和维持正常髓鞘有关；在Trembler小鼠中，轴突或全身异常似乎在这些疾病的发病机制中不起主要作用。
Peripheral nerves of the mutant mouse Trembler are characterized by a severe myelin deficit and an increased number of Schwann cells. On the basis of autoradiographic and quantitative morphologic investigations, the study documents: an abnormal persistence of post-natal Schwann cell proliferation in Trembler mouse nerves which, in unaffected animals, are composed of myelinated fibers; normal morphology, numbers and proliferation of Schwann cells in the unmyelinated (Remak) fibers of Trembler mice; and replication of the increased rate of Schwann cell multiplication and the myelin deficit, when segments of Trembler sciatic nerves are transplanted into the sciatic nerves of normal mice. The continued proliferation of Trembler Schwann cells must be related to the primary inability of these cells to produce and maintain a normal myelin sheath; axonal or general systemic abnormalities do not appear to play a major role in the pathogenesis of these disorders in the Trembler mouse.