l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and mice
l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and mice
复制标题
L-Scoulerine 可减轻斑马鱼和小鼠由甲基苯丙胺引起的行为变化。
DOI：
10.1016/j.bbr.2015.09.039
复制
发表时间：
2016-02-01
影响因子：
2.7
通讯作者：
Yang, Zheng
中科院分区：
文献类型：
--
作者：
Mi, Guiyun;Gao, Yunyun;Yang, Zheng
甲基苯丙胺 (METH) 是一种极有可能被滥用和成瘾的物质，是一个严重的全球公共卫生问题。冰毒成瘾者经常表现出极度偏执、焦虑和抑郁。因此，没有有效的药物来治疗 METH 引起的异常。在本研究中，我们研究了四氢原小檗碱 (THPBS) 生物碱 l-Scoulerine (l-SLR) 对 METH 诱导的斑马鱼焦虑样行为和 METH 诱导的小鼠成瘾行为的影响。在新型水箱测试中，急性施用冰毒 (2 mg/L) 导致总垂直转换次数和在上部区域花费的时间显着减少。此外，在镜子刺激测试中，METH产生了显着的回避行为，表现出中心区域的游泳时间增加和镜子区域的高速运动；这些类似焦虑的变化被 l-SLR 减弱了。长期服用冰毒（2 毫克/千克）可使小鼠的运动活动和条件性位置偏好稳步增加。 l-SLR (5 mg/kg) 未能减少急性 METH 诱导的过度运动，但减弱了慢性 METH 诱导的行为敏化，并显着阻断 METH 诱导的小鼠条件性位置偏好的表达。目前的研究表明，l-SLR 可能是治疗由冰毒引起的成瘾和焦虑的有前途的药物。 (C) 2015 Elsevier B.V. 保留所有权利。
Methamphetamine (METH), a substance with a high potential for abuse and addiction, is a serious worldwide public health problem. METH addicts often show extreme paranoia, anxiety, and depression. Thus, there is no effective medication for the treatment of METH-induced abnormalities. In the present study, we investigated the effects of l-Scoulerine (l-SLR), a tetrahydroprotoberberine (THPBS) alkaloid, on METH-induced anxiety-like behaviour in zebrafish and METH-induced addictive behavior in mice. In the novel tank test, acute administration of METH (2 mg/L) induced a significant decrease in the number of total vertical transitions and time spent in the upper zone. Moreover, METH produced significant avoidance behaviour showing increased swimming time in the central area and high speed movement in the mirror area in the mirror stimulation test; these anxiety-like changes were attenuated by l-SLR. Chronic administration of METH (2 mg/kg) produced a steady increase in locomotor activity and conditioned place preference in mice. l-SLR (5 mg/kg) failed to reduce acute METH-induced hyperlocomotion, but attenuated chronic METH-induced behavioural sensitization and significantly blocked the expression of conditioned place preference induced by METH in mice. The present study suggests that l-SLR may be a promising agent for the treatment of addiction and anxiety induced by METH. (C) 2015 Elsevier B.V. All rights reserved.