Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' disease.
Auto-antibodies to receptor tyrosine kinases TrkA, TrkB and TrkC in patients with chronic Chagas' disease.
复制标题
慢性恰加斯病患者体内受体酪氨酸激酶 TrkA、TrkB 和 TrkC 的自身抗体。
DOI：
10.1111/j.1365-3083.2008.02102.x
复制
发表时间：
2008
影响因子：
3.7
通讯作者：
PereiraPerrin,M
中科院分区：
文献类型：
--
作者：
Lu,B;Petrola,Z;Luquetti,AO;PereiraPerrin,M
The Chagas’ disease parasiteTrypanosoma cruzipromotes survival and differentiation of neurones by binding and activating nerve growth factor (NGF) receptor TrkA. The functional mimic of NGF inT. cruziis a surface‐bound and shed immunogenic protein [neurotrophic factor/trans‐sialidase (TS)], which raised the possibility that immune response toT. cruziin general and to neurotrophic factor/TS in particular leads to loss of immunological tolerance to host NGF and/or the NGF‐binding partner TrkA. In testing this hypothesis, we found that sera of individuals with chronic Chagas’ disease bear unique IgG2 autoantibodies that bind TrkA and TrkA family members TrkB and TrkC (ATA). Binding of ATA to Trk receptors is specific because the autoantibodies did not cross‐react with five other growth factor receptors, NGF and other neurotrophins, andT. cruzi. Thus, individuals with chronic Chagas’ disease produce unique antibodies that react with pan‐Trk receptors, one of which (TrkA)T. cruziexploits to inhibit host cell apoptosis and to promote cellular invasion.
