The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism
The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism
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DOI：
10.1016/j.biopsych.2009.10.009
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发表时间：
2010-02-15
影响因子：
10.6
通讯作者：
De Quervain, Dominique J. -F.
中科院分区：
文献类型：
--
作者：
Kolassa, Iris-Tatjana;Kolassa, Stephan;De Quervain, Dominique J. -F.
背景：创伤后应激障碍（PTSD）的风险取决于在剂量反应关系中经历的创伤事件类型的数量，但已知遗传因素也会影响PTSD的风险。儿茶酚o -甲基转移酶（COMT） Val158Met多态性已被发现影响恐惧消退，并可能在焦虑症的病因学中发挥作用。结果：不同的终生创伤事件类型越多，终生PTSD患病率越高，且呈剂量-反应关系。然而，COMT基因型调节了这种效应：Val等位基因携带者表现出典型的剂量-反应关系，Met/Met纯合子表现出与创伤负荷的严重程度无关的PTSD高风险。结论：目前的研究结果表明，人类COMT Val158Met多态性与PTSD发生风险中经历的创伤事件类型的数量之间存在基因-环境相互作用。
Background: The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.Methods: Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.Results: Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose-response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose-response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.Conclusions: The present findings indicate a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.