Influence of child abuse on adult depression - Moderation by the corticotropin-releasing hormone receptor gene
Influence of child abuse on adult depression - Moderation by the corticotropin-releasing hormone receptor gene
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DOI：
10.1001/archgenpsychiatry.2007.26
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发表时间：
2008-02-01
影响因子：
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通讯作者：
Ressler, Kerry J.
中科院分区：
文献类型：
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作者：
Bradley, Rebekah G.;Binder, Elisabeth B.;Ressler, Kerry J.
背景：遗传和发育性生活压力都会导致成人的主要抑郁障碍。儿童虐待和创伤改变了内源性应激反应，主要是促肾上腺皮质激素释放激素及其下游效应因子，这表明该基因X环境的相互作用在抑郁症中可能是重要的。目的：检查儿童虐待对成人抑郁症状的影响是否受到促肾上腺皮质激素释放激素1型受体(CRHR1)基因内的遗传多态性的调节。设计：考察X基因环境对成人抑郁症状的影响CRHR1基因的遗传多态与虐待儿童的措施对成人抑郁症状的交互作用。地点：一家大型公立城市医院和乔治亚州亚特兰大埃默里大学的普通医疗诊所。参与者：主要参与者：97.4%的非洲裔美国人，美国人，乔治亚州亚特兰大的埃默里大学社会经济地位低，终生创伤发生率高(n=422)。一个支持性的独立样本(n=199)在种族(87.7%的高加索人)和社会经济(较低贫困)两个方面都是不同的。主要观察指标：Beck抑郁问卷评分和DSM-IV轴I障碍结构化临床访谈的严重抑郁障碍史。结果：共检测到15个单核苷酸多态，跨越57kb的CRHR1基因。我们发现X基因环境与多个个体单核苷酸多态(如rs110402，P=.008)以及跨越内含子1的常见单倍型(P
Context: Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene X environment interaction at this locus may be important in depression.Objective: To examine whether the effects of child abuse on adult depressive symptoms are moderated by genetic polymorphisms within the corticotropin- releasing hormone type 1 receptor (CRHR1) gene.Design: Association study examining gene X environment interactions between genetic polymorphisms at the CRHR1 locus and measures of child abuse on adult depressive symptoms.Setting: General medical clinics of a large, public, urban hospital and Emory University, Atlanta, Georgia.Participants: The primary participant population was 97.4% African American, of low socioeconomic status, and with high rates of lifetime trauma (n= 422). A supportive independent sample (n= 199) was distinct both ethnically (87.7% Caucasian) and socioeconomically (less impoverished).Main Outcome Measures: Beck Depression Inventory scores and history of major depressive disorder by the Structured Clinical Interview for DSM- IV Axis I Disorders.Results: Fifteen single-nucleotide polymorphisms spanning 57 kilobases of the CRHR1 gene were examined. We found significant gene X environment interactions with multiple individual single- nucleotide polymorphisms (eg, rs110402, P=. 008) as well as with a common haplotype spanning intron 1 (P