Enzymatic synthesis of optical pure β-nitroalcohols by combining D-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution
Enzymatic synthesis of optical pure β-nitroalcohols by combining D-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution
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DOI：
10.1039/c1gc15417f
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发表时间：
2011-08
期刊：
影响因子：
9.8
通讯作者：
Fangli Xu;Junliang Wang;Bokai Liu;Qi Wu;Xianfu Lin
中科院分区：
文献类型：
--
作者：
Fangli Xu;Junliang Wang;Bokai Liu;Qi Wu;Xianfu Lin
An enzymatic method which combines D-aminoacylase catalyzed nitroaldol reaction and lipase PS-IM catalyzed acyl resolution reaction was constructed to obtain optically pure β-nitroalcohols in organic media under mild conditions. A series of β-nitroalcohols were synthesized and then resolved, with excellent ee values (>95%) and yields mostly, giving enantiomerically pure acetate and alcohol of the opposite configuration simultaneously.
