Identification and Biological Evaluation of Secondary Metabolites from the Endolichenic Fungus Aspergillus versicolor
Identification and Biological Evaluation of Secondary Metabolites from the Endolichenic Fungus Aspergillus versicolor
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内生真菌杂色曲霉次生代谢产物的鉴定及生物学评价
DOI：
10.1002/cbdv.201400146
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发表时间：
2015-04-01
影响因子：
2.9
通讯作者：
Lou, Hong-Xiang
中科院分区：
文献类型：
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作者：
Li, Xiao-Bin;Zhou, Yan-Hui;Lou, Hong-Xiang
从栎衣（Lobaria quercizans）中分离到一株内生真菌Aspergillus versicolor（125 a），经化学分析，分离出4个新的二苯醚类化合物，分别命名为diorcinols F-H（1-3，resp.）和3-甲氧基紫草醇-II（4），8个新的红没药烷型倍半萜类化合物，分别命名为（-）-（R）-环-羟基西唐酸（5），（-）-（7S，8 R）-8-羟基西唐酸（6），（-）-（7 R，10 S）-10-羟基西唐酸（7），（-）-（7 R，10 R）-异-10-羟基西唐酸（8），（-）-12-乙酰氧基-1-脱氧西唐酸（9），（-）-12-乙酰氧基sydonic酸（10），（-）-12-羟基sydonic酸（11）和（-）-（R）-11-脱氢sydonic酸（12），两种新的三（连苯三酚醚），命名为sydowiol D（13）和E（14），和十五种已知化合物，15-29。所有结构都通过光谱分析确定，其中一些结构通过化学转化和电子圆二色性（ECD）计算进一步鉴定。初步的生物测定，这些分离物对真菌白色念珠菌的抑制活性的测定，和对人癌细胞系PC 3，A549，A2780，MDA-MB-231，和HEPG 2的细胞毒性进行了评价。
A chemical investigation of the endolichenic fungus Aspergillus versicolor (125a), which was found in the lichen Lobaria quercizans, resulted in the isolation of four novel diphenyl ethers, named diorcinols F-H (1-3, resp.) and 3-methoxyviolaceol-II (4), eight new bisabolane sesquiterpenoids, named (-)-(R)-cyclo-hydroxysydonic acid (5), (-)-(7S,8R)-8-hydroxysydowic acid (6), (-)-(7R,10S)-10-hydroxysydowic acid (7), (-)-(7R,10R)-iso-10-hydroxysydowic acid (8), (-)-12-acetoxy-1-deoxysydonic acid (9), (-)-12-acetoxysydonic acid (10), (-)-12-hydroxysydonic acid (11), and (-)-(R)-11-dehydrosydonic acid (12), two new tris(pyrogallol ethers), named sydowiols D (13) and E (14), and fifteen known compounds, 15-29. All of the structures were determined by spectroscopic analyses, and a number of them were further identified through chemical transformations and electronic circular dichroism (ECD) calculations. Preliminary bioassays of these isolates for the determination of their inhibitory activities against the fungus Candida albicans, and their cytotoxicities against the human cancer cell lines PC3, A549, A2780, MDA-MB-231, and HEPG2 were also evaluated.