Green tea consumption and stomach cancer risk: a meta-analysis.
Green tea consumption and stomach cancer risk: a meta-analysis.
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DOI：
10.4178/epih/e2010001
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发表时间：
2010-04-26
影响因子：
3.8
通讯作者：
Nam CM
中科院分区：
文献类型：
--
作者：
Kang H;Rha SY;Oh KW;Nam CM
绿茶被认为对包括胃癌在内的多种癌症具有化学预防作用。本研究的目的是通过荟萃分析阐明绿茶消费与胃癌风险之间的关系。使用 MEDLINE、THE COCHRANE LIBRARY、RISS 和手动检索确定了 18 项观察性研究。根据固定效应模型和随机效应模型计算了最高绿茶消费水平与非/最低绿茶消费水平的相对风险/比值比 (RR/OR)。亚组分析用于检查研究之间的异质性。综合结果表明，摄入绿茶可降低患胃癌的风险（RR/OR=0.86，95% CI=0.74-1.00）。六项研究报告的最高和最低摄入水平之间的差异等于或大于每天五杯的亚组分析显示，具有统计学上显着的保护作用（RR/OR=0.68，95% CI=0.53-0.87）。绿茶似乎对预防胃癌的发展具有保护作用。研究结果还表明，可能需要摄入更高水平的绿茶才能出现明显的预防效果。然而，应该谨慎解释这一结论，因为各种偏差都会影响荟萃分析的结果。
Green tea has been suggested to have a chemopreventive effect against various cancers including stomach cancer. The aim of this study is to elucidate the relationship between green tea consumption and stomach cancer risk by meta-analysis. Eighteen observational studies were identified using MEDLINE, THE COCHRANE LIBRARY, RISS, and a manual search. Summary relative risks/odds ratios (RR/ORs) for the highest versus non/lowest green tea consumption levels were calculated on the basis of fixed and random effect models. Subgroup analyses were used to examine heterogeneity across the studies. The combined results indicate a reduced risk of stomach cancer with intake of green tea (RR/OR=0.86, 95% CI=0.74-1.00). Subgroup analysis with six studies that reported differences between the highest and lowest consumption levels equal to or greater than five cups/day revealed a statistically significant protective effect (RR/OR=0.68, 95% CI=0.53-0.87). Green tea appears to play a protective role against the development of stomach cancer. The results also suggest that a higher level of green tea consumption might be needed for a clear preventive effect to appear. This conclusion, however, should be interpreted with caution because various biases can affect the results of a meta-analysis.