Regulation of muscle protein synthesis and the effects of catabolic states.
Regulation of muscle protein synthesis and the effects of catabolic states.
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DOI：
10.1016/j.biocel.2013.05.039
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发表时间：
2013-10
影响因子：
4
通讯作者：
Kimball, Scot R.
中科院分区：
文献类型：
--
作者：
Gordon, Bradley S.;Kelleher, Andrew R.;Kimball, Scot R.
蛋白质的合成和降解是动态调节的过程，其协同作用以控制肌肉质量的增加或损失。本文重点介绍与骨骼肌萎缩相关的蛋白质合成障碍的机制。已知调节蛋白质合成的绝大多数机制涉及mRNA翻译起始阶段的调节，其包括导致起始剂甲硫氨酰-tRNAi和mRNA与40 S核糖体亚基结合的一系列反应。参与这两种事件的蛋白质的功能已被证明在萎缩性疾病如脓毒症、恶病质、慢性肾病、肌肉减少症和废用性萎缩下受到抑制。在这种情况下抑制蛋白质合成的基础可能是多因素的，包括胰岛素/胰岛素样生长因子1抵抗、促炎细胞因子表达、营养不良、皮质类固醇和/或身体活动不足。本文提供了一个概述现有的文献有关的机制和信号通路参与调控的mRNA翻译，因为它们适用于骨骼肌萎缩，以及潜在的临床干预措施，如营养和运动在维持骨骼肌蛋白质合成萎缩条件下的疗效。
Protein synthesis and degradation are dynamically regulated processes that act in concert to control the accretion or loss of muscle mass. The present article focuses on the mechanisms involved in the impairment of protein synthesis that are associated with skeletal muscle atrophy. The vast majority of mechanisms known to regulate protein synthesis involve modulation of the initiation phase of mRNA translation, which comprises a series of reactions that result in the binding of initiator methionyl-tRNAi and mRNA to the 40S ribosomal subunit. The function of the proteins involved in both events has been shown to be repressed under atrophic conditions such as sepsis, cachexia, chronic kidney disease, sarcopenia, and disuse atrophy. The basis for the inhibition of protein synthesis under such conditions is likely to be multifactorial and includes insulin/insulin-like growth factor 1 resistance, pro-inflammatory cytokine expression, malnutrition, corticosteroids, and/or physical inactivity. The present article provides an overview of the existing literature regarding mechanisms and signaling pathways involved in the regulation of mRNA translation as they apply to skeletal muscle wasting, as well as the efficacy of potential clinical interventions such as nutrition and exercise in the maintenance of skeletal muscle protein synthesis under atrophic conditions.
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影响因子：
4.8
作者：
COLEMAN, ME;DEMAYO, F;SCHWARTZ, RJ
通讯作者：
SCHWARTZ, RJ
影响因子：
8.8
作者：
Eley, H. L.;Skipworth, R. J. E.;Deans, D. A. C.;Fearon, K. C. H.;Tisdale, M. J.
通讯作者：
Tisdale, M. J.
影响因子：
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作者：
Balage, Michele;Averous, Julien;Dardevet, Dominique
通讯作者：
Dardevet, Dominique
影响因子：
5.5
作者：
Constantin, Despina;McCullough, Justine;Greenhaff, Paul L.
通讯作者：
Greenhaff, Paul L.
DOI：
10.1152/ajpendo.00603.2011
发表时间：
2012-05-01
影响因子：
5.1
作者：
Drummond, Micah J.;Dickinson, Jared M.;Volpi, Elena
通讯作者：
Volpi, Elena