Estimation of caffeine intake from analysis of caffeine metabolites in wastewater
Estimation of caffeine intake from analysis of caffeine metabolites in wastewater
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DOI：
10.1016/j.scitotenv.2017.07.258
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发表时间：
2017-12-31
影响因子：
9.8
通讯作者：
Castiglioni, Sara
中科院分区：
文献类型：
--
作者：
Gracia-Lor, Emma;Rousis, Nikolaos I.;Castiglioni, Sara
研究了废水中的咖啡因代谢物作为评估人群咖啡因摄入量的潜在生物标志物。在欧洲10个城市的城市废水中测定了咖啡因的主要人体尿液代谢产物，并将废水中的代谢谱与人体尿液排泄谱进行了比较。发现1，7-二甲基尿酸（一种独特的咖啡因代谢物）具有很好的匹配性，这表明它可能是废水中评估人群咖啡因消耗量的合适生物标志物。根据已发表的药代动力学研究，考虑到该代谢物在人体内的排泄百分比，开发了校正因子。通过废水分析估计的每日咖啡因摄入量与根据各国人均咖啡消费量计算的平均每日摄入量进行了比较。在一些城市发现了良好的一致性，但需要进一步的信息来规范这种方法。废水分析证明是有用的，提供额外的当地信息的咖啡因使用。(C)2017 Elsevier B. V.版权所有。
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use. (C) 2017 Elsevier B.V. All rights reserved.