Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats
Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats
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DOI：
10.1161/hypertensionaha.113.02809
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发表时间：
2014-08-01
期刊：
影响因子：
8.3
通讯作者：
Denton, Kate M.
中科院分区：
文献类型：
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作者：
Hilliard, Lucinda M.;Chow, Charis L. E.;Denton, Kate M.
越来越多的证据表明，女性的肾素-血管紧张素系统的保护途径增强，包括血管紧张素2型受体（AT（2）R），它介导血管舒张和利钠作用。为了深入了解药物刺激AT（2）R调节高血压肾功能的性别特异性能力，我们检测了AT（2）R激动剂化合物21（100-300 ng/kg/min）对18- 19周龄麻醉雄性和雌性自发性高血压大鼠肾功能的影响。AT（2）R刺激显著增加雌性高血压大鼠的肾血流量（P
Accumulating evidence suggests that the protective pathways of the renin-angiotensin system are enhanced in women, including the angiotensin type 2 receptor (AT(2)R), which mediates vasodilatory and natriuretic effects. To provide insight into the sex-specific ability of pharmacological AT(2)R stimulation to modulate renal function in hypertension, we examined the influence of the AT(2)R agonist, compound 21 (100-300 ng/kg per minute), on renal function in 18- to 19-week-old anesthetized male and female spontaneously hypertensive rats. AT(2)R stimulation significantly increased renal blood flow in female hypertensive rats (P-Treatment