Advances in alcoholic liver disease.
Advances in alcoholic liver disease.
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DOI：
10.1155/2012/563018
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发表时间：
2012
影响因子：
1.8
通讯作者：
Dolganiuc A
中科院分区：
文献类型：
--
作者：
Osna N;Kharbanda K;Schrum L;Dolganiuc A
这一特刊反映了ALD发病机制中涉及的多种因素/机制。众所周知，酒精性肝损伤会导致广泛的肝脏异常。酒精主要在肝细胞中代谢，导致炎症介质分泌增加，进而激活和/或影响非实质细胞（NPC）（肝星状细胞，枯否细胞和窦内皮细胞）的反应，并随后控制肝损伤的程度。Ambade和P. Mandrekar）以及这些事件的分子方面，包括乙醇代谢酶ADH（T. Haseba等人），和CYP2E1（AI Cederbaum et al.）酒精性肝损伤的发展。此外，LN Gerjevic等人的论文中研究了酒精诱导的信号传导机制。巴拉和G. Szabo.
This special issue reflects on multiple factors/mechanisms involved in the pathogenesis of ALD. Alcoholic liver injury is known to cause a broad range of liver abnormalities. Alcohol is primarily metabolized in the hepatocyte leading to increased secretion of inflammatory mediators, which, in turn, activate and/or influence the response of the nonparenchymal cells (NPCs)(hepatic stellate cells, Kupffer cells, and sinusoidal endothelial cells) and subsequently control the degree of liver injury.This issue overviews general aspects of ALD, such as oxidative stress and inflammation (A. Ambade and P. Mandrekar) as well as the molecular aspects of these events, including the role of ethanol-metabolizing enzymes, ADH (T. Haseba et al.), and CYP2E1 (AI Cederbaum et al.) in the development of alcohol-induced liver injury. In addition, signaling mechanisms induced by alcohol are examined in the paper by LN Gerjevic et al. As a separate pathogenic aspect, the role of microRNA in ALD is analyzed in the paper by S. Bala and G. Szabo.